Haruhiko Bito

Profile Information

Affiliation: Professor and Chair of Neurochemistry, Graduate School of Medicine, The University of Tokyo

Degree: M.D., Ph.D.(The University of Tokyo)

J-GLOBAL ID: 201101049958120562
researchmap Member ID: B000001382

External link: http://www.neurochem.m.u-tokyo.ac.jp/Homepage.html

Research Interests

Papers

132

Experience-dependent changes in affective valence of taste in male mice.

Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka, Ayako M Watabe

Molecular brain, 16(1) 28-28, Mar 11, 2023
Arc controls alcohol cue relapse by a central amygdala mechanism.

Roberto Pagano, Ahmad Salamian, Janusz Zielinski, Anna Beroun, Maria Nalberczak-Skóra, Edyta Skonieczna, Anna Cały, Nicole Tay, Tobias Banaschewski, Sylvane Desrivières …

Molecular psychiatry, Nov 10, 2022
A genetically encoded far-red fluorescent calcium ion biosensor derived from a biliverdin-binding protein.

Rina Hashizume, Hajime Fujii, Sohum Mehta, Keisuke Ota, Yong Qian, Wenchao Zhu, Mikhail Drobizhev, Yusuke Nasu, Jin Zhang, Haruhiko Bito …

Protein science : a publication of the Protein Society, 31(10) e4440, Oct, 2022
A non-invasive system to monitor in vivo neural graft activity after spinal cord injury.

Kentaro Ago, Narihito Nagoshi, Kent Imaizumi, Takahiro Kitagawa, Momotaro Kawai, Keita Kajikawa, Reo Shibata, Yasuhiro Kamata, Kota Kojima, Munehisa Shinozaki …

Communications biology, 5(1) 803-803, Aug 10, 2022 Peer-reviewed
In Vivo Wide-Field and Two-Photon Calcium Imaging from a Mouse using a Large Cranial Window.

Satoshi Manita, Eiji Shigetomi, Haruhiko Bito, Schuichi Koizumi, Kazuo Kitamura

Journal of visualized experiments : JoVE, (186), Aug 4, 2022 Peer-reviewed
Functional correlates of immediate early gene expression in mouse visual cortex.

David Mahringer, Pawel Zmarz, Hiroyuki Okuno, Haruhiko Bito, Georg B Keller

Peer community journal, 2 e45, Jul 29, 2022
In utero electroporation and cranial window implantation for in vivo wide-field two-photon calcium imaging using G-CaMP9a transgenic mice.

Masayuki Sakamoto, Keisuke Ota, Yayoi Kondo, Michiko Okamura, Hajime Fujii, Haruhiko Bito

STAR protocols, 3(2) 101421-101421, Jun 17, 2022 Peer-reviewed
Deciphering Ca2+-controlled biochemical computation governing neural circuit dynamics via multiplex imaging.

Hajime Fujii, Haruhiko Bito

Neuroscience research, 179 79-90, Jun, 2022 Peer-reviewed
Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area.

Fumiko Goto, Yuji Kiyama, Itone Ogawa, Hiroyuki Okuno, Taeko Ichise, Hirotake Ichise, Motonobu Anai, Tatsuhiko Kodama, Nobuaki Yoshida, Haruhiko Bito …

Molecular psychiatry, 27(3) 1694-1703, Mar, 2022 Peer-reviewed
A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo.

Masayuki Sakamoto, Masatoshi Inoue, Atsuya Takeuchi, Shigetaka Kobari, Tatsushi Yokoyama, Shin-Ichiro Horigane, Sayaka Takemoto-Kimura, Manabu Abe, Kenji Sakimura, Masanobu Kano …

Cell reports methods, 2(2) 100168-100168, Feb 28, 2022 Peer-reviewed
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder.

Chenyao Wang, Shin-Ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura …

Translational psychiatry, 12(1) 84-84, Feb 26, 2022 Peer-reviewed
Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability.

Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-Ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito

Frontiers in molecular neuroscience, 15 970031-970031, 2022 Peer-reviewed
Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia.

Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima-Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya …

EMBO molecular medicine, 13(4) e12574, Apr 9, 2021 Peer-reviewed
Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles.

Shuhei Ueda, Masahito Hosokawa, Koji Arikawa, Kiyofumi Takahashi, Mao Fujiwara, Manami Kakita, Taro Fukada, Hiroaki Koyama, Shin-Ichiro Horigane, Keiichi Itoi …

Frontiers in molecular neuroscience, 14 741895-741895, 2021 Peer-reviewed
Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models.

Machi Horiai, Ayano Otsuka, Shizu Hidema, Yuichi Hiraoka, Ryotaro Hayashi, Shinji Miyazaki, Tamio Furuse, Hiroaki Mizukami, Ryoichi Teruyama, Masaru Tamura …

Scientific reports, 10(1) 22173-22173, Dec 17, 2020 Peer-reviewed
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.

Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya

Cerebral cortex (New York, N.Y. : 1991), Nov 30, 2020 Peer-reviewed
A Photodeactivatable Antagonist for Controlling CREB-Dependent Gene Expression.

Takuma Imoto, Masafumi Minoshima, Tatsushi Yokoyama, Ben P Emery, Steven D Bull, Haruhiko Bito, Kazuya Kikuchi

ACS central science, 6(10) 1813-1818, Oct 28, 2020 Peer-reviewed
Comparative Studies of the Fluorescence Properties of Microbial Rhodopsins: Spontaneous Emission Versus Photointermediate Fluorescence.

Keiichi Kojima, Rika Kurihara, Masayuki Sakamoto, Tsukasa Takanashi, Hikaru Kuramochi, Xiao Min Zhang, Haruhiko Bito, Tahei Tahara, Yuki Sudo

The journal of physical chemistry. B, 124(34) 7361-7367, Aug 27, 2020 Peer-reviewed
Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons.

Shin-Ichiro Horigane, Shun Hamada, Satoshi Kamijo, Hirokazu Yamada, Miwako Yamasaki, Masahiko Watanabe, Haruhiko Bito, Toshihisa Ohtsuka, Sayaka Takemoto-Kimura

Neuroscience research, Jun 26, 2020 Peer-reviewed
Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes.

Hirotaka Fujita, Ryota Oikawa, Mayu Hayakawa, Fumiaki Tomoike, Yasuaki Kimura, Hiroyuki Okuno, Yoshiki Hatashita, Carolina Fiallos Oliveros, Haruhiko Bito, Toshio Ohshima …

The Journal of biological chemistry, 295(23) 7923-7940, Jun 5, 2020 Peer-reviewed

Misc.

革新脳と関連プロジェクトから見えてきた新しい脳科学 II.脳機能マッピングのための新規技術開発新規高性能カルシウムセンサー分子設計から脳神経回路の情報動態解明へ

井上昌俊, 井上昌俊, 藤井哉, 坂本雅行, 坂本雅行, 尾藤晴彦

生体の科学, 73(5), 2022
Nrp2+mitral cells in the main olfactory bulb send axons to the medial amygdala to induce social behaviors

Kasumi Inokuchi, Haruki Takeuchi, Fumiaki Imamura, Ryang Kim, Hiroyuki Okuno, Hirofumi Nishizumi, Haruhiko Bito, Takefumi Kikusui, Hitoshi Sakano

CHEMICAL SENSES, 41(9) E148-E149, Nov, 2016
【記憶ふたたび】シナプスと記憶シナプスと核の間の二方向性シグナリングの意義

酒井一輝, 金亮, 奧野浩行, 尾藤晴彦

生体の科学, 67(1) 4-8, Feb, 2016
基礎医学研究者育成プログラムの現状と今後の課題について

小松紀子, 菅谷佑樹, 本田郁子, 尾藤晴彦, 吉川雅英

日本生理学雑誌, 78(1) 13-15, Jan, 2016
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2 (vol 12, pg 64, 2015)

Masatoshi Inoue, Atsuya Takeuchi, Shin-ichiro Horigane, Masamichi Ohkura, Keiko Gengyo-Ando, Hajime Fujii, Satoshi Kamijo, Sayaka Takemoto-Kimura, Masanobu Kano, Junichi Nakai …

NATURE METHODS, 12(9) 893-893, Sep, 2015
【脳神経回路リモデリングヒトの個性と心の根源への挑戦+特別フォーラム】フォーラムこれからの脳神経研究を考える光ベースの脳神経研究のこれから全光ベース神経情報計測・操作プラットフォームを駆使し、脳の普遍性・ユニークさの解明を!

尾藤晴彦

実験医学, 33(9) 1400-1401, Jun, 2015
超高感度･超高速な赤色Ca2+センサー『R-CaMP2』の開発による神経活動の可視化

井上昌俊, 尾藤晴彦

実験医学, -m-inoue, May, 2015
核からシナプスへの分子ターゲティング機構の解明神経回路の長期可塑性を制御するArcタンパク質のケーススタディ

奥野浩行, 尾藤晴彦

生化学, 86(1) 18-26, Feb, 2014
神経活動を可視化する超高感度かつ超高速の赤色Ca2+センサーの開発

井上昌俊, 尾藤晴彦

ライフサイエンス新着論文レビュー, 2014
The role of Arc in inverse tagging of inactive synapses

H. Okuno, H. Bito, T. Kawashima, M. Nonaka, M. Inoue, H. Fujii, Y. Ishii

JOURNAL OF NEUROCHEMISTRY, 125 43-43, May, 2013
活動依存的な遺伝子発現誘導・突起伸展機構

尾藤晴彦

ブレインサイエンス・レビュー, 2013 155-168, Feb, 2013
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation

N. Ageta-Ishihara, T. Miyata, H. Bito, M. Kinoshita

MOLECULAR BIOLOGY OF THE CELL, 24, 2013
Nuclear translocation of CRTC1 triggers neuronal activity-dependent gene expression and enhances long-term memory

M. Nonaka, H. Fukushima, K. Sasaki, K. Suzuki, T. Kawashima, H. Okuno, S. Kida, H. Bito

JOURNAL OF NEUROCHEMISTRY, 123 40-40, Oct, 2012
新しいプレクリニカルの技術展開―トランスレーションに向けて―2.光技術を用いた神経回路機能の解読と操作

尾藤晴彦, 松崎政紀, 吉村由美子, 古田寿昭

実験医学, 30(13) 2080-2086, Aug 1, 2012
Basic Neuroscience 生化学脳の可塑性

野中美応, 金亮, 奥野浩行, 尾藤晴彦

Annual Review神経, 2012 43-49, Jan, 2012
Differential usage of the Arc/Arg3.1 gene promoter by the BDNF- and the neuronal activity-induced transcription activation in neurons

Masaaki Tsuda, Mamoru Fukuchi, Masataka Shimotori, Saori Tatsumi, Akiko Tabuchi, Takashi Kawashima, Hiroyuki Okuno, Haruhiko Bito

NEUROSCIENCE RESEARCH, 71 E114-E114, 2011
Feature extraction and combinatorial representation of neuronal input pattern by Ca2+ signaling pathways

Hajime Fujii, Masatoshi Inoue, Hiroyuki Okuno, Sayaka Takemoto-Kimura, Haruhiko Bito

NEUROSCIENCE RESEARCH, 71 E116-E116, 2011
Deciphering Ca2+ signaling during radial migration of immature cortical neurons

Shin-ichiro Horigane, Sayaka Takemoto-Kimura, Aki Adachi-Morishima, Satoshi Kamijo, Kanzou Suzuki, Michiko Okamura, Hiroyuki Okuno, Haruhiko Bito

NEUROSCIENCE RESEARCH, 71 E129-E129, 2011
Molecular basis of CLICK-III/CaMKI gamma-mediated dendritogenesis in developing cortical neurons

Kanzo Suzuki, Sayaka Takemoto-Kimura, Satoshi Kamijo, Masatoshi Inoue, Hajime Fujii, Natsumi Ageta-Ishihara, Hiroyuki Okuno, Haruhiko Bito

NEUROSCIENCE RESEARCH, 71 E67-E67, 2011
Regulation of radial migration of cortical pyramidal neurons by a Ca2+/calmodulin-dependent protein kinase I cascade

Shin-ichirou Horigane, Sayaka Takemoto-Kimura, Aki Adachi-Morishima, Natsumi Ageta-Ishihara, Kanzou Suzuki, Mio Nonaka, Michiko Okamura, Yoshiaki V. Nishimura, Takeshi Kawauchi, Kazunori Nakajima …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 132P-132P, 2011

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