2010年7月
Differential roles for CaM kinases in mediating excitation-morphogenesis coupling during formation and maturation of neuronal circuits
EUROPEAN JOURNAL OF NEUROSCIENCE
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- 巻
- 32
- 号
- 2
- 開始ページ
- 224
- 終了ページ
- 230
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1460-9568.2010.07353.x
- 出版者・発行元
- WILEY-BLACKWELL
Ca(2+)-regulated reorganization of actin cytoskeleton is one of the key cell biological events that critically regulate neuronal morphogenesis during circuit formation, spinogenesis during synapse development, and activity-dependent structural plasticity at mature synapses. However, it remains unclear as to what extent the underlying Ca(2+) signaling processes are shared or segregated. Here, we present evidence from the literature that collectively begins to suggest that distinct calmodulin-dependent protein kinase (CaMK) isoforms are differentially expressed in time and in subcellular space, and thus may be selectively activated and engaged by distinct upstream stimuli; each CaMK isoform, in turn, couples to related, but separate, cytoskeletal and transcriptional regulatory pathways, dependent on its abundance or physical proximity with either the upstream or downstream signaling complexes. These signal transduction characteristics provide the basis for better understanding the role of excitation-morphogenesis coupling via multiple CaMKs during neuronal circuit and synapse formation.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1460-9568.2010.07353.x
- ISSN : 0953-816X
- PubMed ID : 20946112
- Web of Science ID : WOS:000280631500007