論文

国際誌
2021年4月3日

Mitophagy regulation mediated by the Far complex in yeast

Autophagy
  • Kentaro Furukawa
  • ,
  • Aleksei Innokentev
  • ,
  • Tomotake Kanki

17
4
開始ページ
1042
終了ページ
1043
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/15548627.2021.1885184
出版者・発行元
Informa UK Limited

Mitochondrial autophagy (mitophagy) selectively degrades mitochondria and plays an important role in mitochondrial homeostasis. In the yeast Saccharomyces cerevisiae, the phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 is essential for mitophagy, whereas this phosphorylation is counteracted by the protein phosphatase Ppg1. Although Ppg1 functions cooperatively with the Far complex (Far3, Far7, Far8, Vps64/Far9, Far10 and Far11), their relationship and the underlying phosphoregulatory mechanism of Atg32 remain unclear. Our recent study revealed: (i) the Far complex plays its localization-dependent roles, regulation of mitophagy and target of rapamycin complex 2 (TORC2) signaling, via the mitochondria- and endoplasmic reticulum (ER)-localized Far complexes, respectively; (ii) Ppg1 and Far11 form a subcomplex, and Ppg1 activity is required to assemble the sub- and core-Far complexes; (iii) association and dissociation between the Far complex and Atg32 are crucial determinants for mitophagy regulation. Here, we summarize our findings and discuss unsolved issues.

リンク情報
DOI
https://doi.org/10.1080/15548627.2021.1885184
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33530805
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078710
URL
https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1885184
ID情報
  • DOI : 10.1080/15548627.2021.1885184
  • ISSN : 1554-8627
  • eISSN : 1554-8635
  • PubMed ID : 33530805
  • PubMed Central 記事ID : PMC8078710

エクスポート
BibTeX RIS