論文

査読有り
2015年8月

Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study

JOURNAL OF HYPERTENSION
  • Michihiro Satoh
  • Miki Hosaka
  • Kei Asayama
  • Masahiro Kikuya
  • Ryusuke Inoue
  • Hirohito Metoki
  • Megumi Tsubota-Utsugi
  • Azusa Hara
  • Takuo Hirose
  • Taku Obara
  • Kazuhito Totsune
  • Haruhisa Hoshi
  • Nariyasu Mano
  • Koichi Node
  • Yutaka Imai
  • Takayoshi Ohkubo
  • 全て表示

33
8
開始ページ
1536
終了ページ
1541
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/HJH.0000000000000570
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Background:
In addition to day-to-day variability in blood pressure (BP) or heart rate (HR), N-terminal pro B-type natriuretic peptide (NT-proBNP) has been reported to be a predictor of cardiovascular disease. Here, we tested the hypothesis that day-to-day BP or HR variability calculated as the intraindividual standard deviation (SD) of home BP or HR is associated with elevated NT-proBNP in a cross-sectional study.
Methods:
Among 664 participants (mean age, 61.9 years; female, 70.5%) from a general Japanese population without a history of heart disease, 86 (13.0%) had NT-proBNP at least 125 pg/ml.
Results:
Each 1 SD increase in the SD of home systolic BP (SBP) [odds ratio (OR), 1.82; P < .0001) and in the SD of home HR (OR, 1.44; P = 0.008) were significantly associated with the prevalence of NT-proBNP at least 125 pg/ml after adjustment for possible confounding factors including home SBP and HR. Among the four groups defined by the median SD of home SBP and of home HR, the group with higher SDs in home SBP (>= 8.0 mmHg) and HR (>= 5.0 bpm) had the greatest OR for the prevalence of NT-proBNP at least 125 pg/ml (OR, 4.80; P = 0007 vs. a reference group with lower SDs of home SBP and HR).
Conclusion:
These results suggest that day-to-day variability in BP and HR may be associated with target-organ damage or complications, which can lead to an elevated NT-proBNP level. An elevated NT-proBNP level may be involved in the prognostic significance of day-to-day variability in BP or HR.

リンク情報
DOI
https://doi.org/10.1097/HJH.0000000000000570
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25827428
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000360853900009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1097/HJH.0000000000000570
  • ISSN : 0263-6352
  • eISSN : 1473-5598
  • PubMed ID : 25827428
  • Web of Science ID : WOS:000360853900009

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