論文

査読有り 筆頭著者 国際誌
2021年1月14日

Novel genetic characteristics of multifocal micronodular pneumocyte hyperplasia (MMPH): a case report with frequent BRAF mutations analyzed by next-generation sequencing supporting benign behaviors of MMPH.

Virchows Archiv : an international journal of pathology
  • Chihiro Inoue
  • ,
  • Ryoko Saito
  • ,
  • Satsuki Kishikawa
  • ,
  • Takuo Hayashi
  • ,
  • Toshio Kumasaka
  • ,
  • Takehiro Yamada
  • ,
  • Hisashi Oishi
  • ,
  • Yuto Yamazaki
  • ,
  • Fumiyoshi Fujishima
  • ,
  • Mika Watanabe
  • ,
  • Hironobu Sasano

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00428-020-03013-1

A woman in her 30s, who was clinically diagnosed with tuberous sclerosis complex, underwent lung transplantation due to lymphangioleiomyomatosis with concomitant multifocal micronodular pneumocyte hyperplasia (MMPH). Histologically, MMPH lesions demonstrated variety in histology; some showed homogenous cells with mild nuclear atypia and elastic fibers proliferation, and the others showed enlarged nuclei without elastic fibers. Because the natural history of MMPH is not well characterized, we used next-generation sequencing to perform a comprehensive genetic analysis for the MMPH lesions to explore their malignant potential. Regardless of their histological variety, three of four lesions had BRAF missense mutations, especially the types frequently detected in atypical adenomatous hyperplasia that is considered to be benign rather than a precursor of adenocarcinoma. None of them had major driver mutations of lung adenocarcinoma, except for BRAF mutations. In conclusion, our study of the lesions from this patient indicated the benign characteristic of MMPH.

リンク情報
DOI
https://doi.org/10.1007/s00428-020-03013-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33443622
ID情報
  • DOI : 10.1007/s00428-020-03013-1
  • PubMed ID : 33443622

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