澤城大悟 (Daigo SAWAKI) - マイポータル

基本情報

所属: 自治医科大学地域医療学センター　地域医療学部門学内准教授

研究者番号: 40456132
ORCID iD: https://orcid.org/0000-0003-1417-2033
J-GLOBAL ID: 202301010250577706
researchmap会員ID: R000058542

論文

Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite

Tatsuyuki Sato, Takayuki Isagawa, Yuki Sugiura, Daigo Sawaki, Yu Nakagama, Takahiro Kuchimaru, Shun Minatsuki, Shigeru Sato, Kazutoshi Ono, Ariunbold Chuluun-Erdene …

Journal of Pharmacological Sciences 160(4) 221-231 2026年4月
Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model.

Daigo Sawaki, Takayuki Isagawa, Shigeru Sato, Tatsuyuki Sato, Hiroaki Semba, Hiroki Sugimoto, Kazutoshi Ono, Ariunbold Chuluun-Erdene, Thuc Toan Pham, Ryohei Tanaka …

European heart journal open 6(1) oeaf178 2026年1月
LPS induces limited activation of hypoxia-inducible factor-1α in macrophages

Takayuki Isagawa, Masaki Suimye Morioka, Hiroaki Semba, Daigo Sawaki, Tatsuyuki Sato, Masaki Wake, Hiroki Sugimoto, Shigeru Sato, Kazutoshi Ono, Chuluun-Erdene Ariunbold …

Journal of Biological Chemistry 301(12) 110932-110932 2025年12月
Multi-Omics of Familial Thoracic Aortic Aneurysm and Dissection: Calcium Transport Impairment Predisposes Aortas to Dissection.

Shota Tomida, Tamaki Ishima, Daigo Sawaki, Yasushi Imai, Ryozo Nagai, Kenichi Aizawa

International journal of molecular sciences 24(20) 2023年10月16日
Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction.

Daigo Sawaki, Yanyan Zhang, Amel Mohamadi, Maria Pini, Zaineb Mezdari, Larissa Lipskaia, Suzain Naushad, Lucille Lamendour, Dogus Murat Altintas, Marielle Breau …

JCI insight 8(8) 2023年4月24日
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.

Gabor Czibik, Zaineb Mezdari, Dogus Murat Altintas, Juliette Bréhat, Maria Pini, Thomas d'Humières, Thaïs Delmont, Costin Radu, Marielle Breau, Hao Liang …

Circulation 144(7) 559-574 2021年8月17日
Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure.

Maria Pini, Gabor Czibik, Daigo Sawaki, Zaineb Mezdari, Laura Braud, Thaïs Delmont, Raquel Mercedes, Cécile Martel, Nelly Buron, Geneviève Marcelin …

Aging cell 20(8) e13421 2021年8月
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.

Nathalie Mougenot, Delphine Mika, Gabor Czibik, Elizabeth Marcos, Shariq Abid, Amal Houssaini, Benjamin Vallin, Aziz Guellich, Hind Mehel, Daigo Sawaki …

Cardiovascular research 115(12) 1778-1790 2019年10月1日
Response by Sawaki et al to Letter Regarding Article, "Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production".

Daigo Sawaki, Gabor Czibik, Maria Pini, Zaineb Mezdari, Yanyan Zhang, Corneliu Henegar, Geneviève Derumeaux

Circulation 139(6) 845-846 2019年2月5日
Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice.

Laura Braud, Maria Pini, Lucie Muchova, Sylvie Manin, Hiroaki Kitagishi, Daigo Sawaki, Gabor Czibik, Julien Ternacle, Geneviève Derumeaux, Roberta Foresti …

JCI insight 3(22) 2018年11月15日
Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production.

Daigo Sawaki, Gabor Czibik, Maria Pini, Julien Ternacle, Nadine Suffee, Raquel Mercedes, Geneviève Marcelin, Mathieu Surenaud, Elisabeth Marcos, Philippe Gual …

Circulation 138(8) 809-822 2018年8月21日
Weight loss to rejuvenate the heart.

Geneviève Derumeaux, Laura Ernande, Daigo Sawaki

European heart journal. Cardiovascular Imaging 19(2) 143-144 2018年2月1日
Association of subclinical carotid atherosclerosis with immediate memory and other cognitive functions.

Lumine Matsumoto, Kazushi Suzuki, Yoshiko Mizuno, Yumiko Ohike, Atsuko Ozeki, Satoshi Ono, Mikio Takanashi, Daigo Sawaki, Toru Suzuki, Tsutomu Yamazaki …

Geriatrics & gerontology international 18(1) 65-71 2018年1月
Short-term high-fat diet compromises myocardial function: a radial strain rate imaging study.

Julien Ternacle, Feng Wan, Daigo Sawaki, Mathieu Surenaud, Maria Pini, Raquel Mercedes, Laura Ernande, Etienne Audureau, Jean-Luc Dubois-Rande, Serge Adnot …

European heart journal. Cardiovascular Imaging 18(11) 1283-1291 2017年11月1日
Clinical Implications of Echocardiographic Phenotypes of Patients With Diabetes Mellitus.

Laura Ernande, Etienne Audureau, Christine L Jellis, Cyrille Bergerot, Corneliu Henegar, Daigo Sawaki, Gabor Czibik, Chiara Volpi, Florence Canoui-Poitrine, Hélène Thibault …

Journal of the American College of Cardiology 70(14) 1704-1716 2017年10月3日
Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria.

Nadine Suffee, Thomas Moore-Morris, Patrick Farahmand, Catherine Rücker-Martin, Gilles Dilanian, Magali Fradet, Daigo Sawaki, Geneviève Derumeaux, Pascal LePrince, Karine Clément …

Proceedings of the National Academy of Sciences of the United States of America 114(5) E771-E780 2017年1月31日
Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.

Feng Wan, Emmanuel Letavernier, Shariq Abid, Amal Houssaini, Gabor Czibik, Elisabeth Marcos, Dominique Rideau, Aurélien Parpaleix, Larissa Lipskaia, Valérie Amsellem …

American journal of respiratory cell and molecular biology 55(3) 337-51 2016年9月
Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.

Amal Houssaini, Shariq Abid, Geneviève Derumeaux, Feng Wan, Aurélien Parpaleix, Dominique Rideau, Elisabeth Marcos, Kanny Kebe, Gabor Czibik, Daigo Sawaki …

American journal of respiratory cell and molecular biology 55(3) 352-67 2016年9月
Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension.

Aurélien Parpaleix, Valérie Amsellem, Amal Houssaini, Shariq Abid, Marielle Breau, Elisabeth Marcos, Daigo Sawaki, Marion Delcroix, Rozenn Quarck, Aurélie Maillard …

The European respiratory journal 48(2) 470-83 2016年8月
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture.

Eriko Hasumi, Katsuhito Fujiu, Teruhiko Imamura, Hiroshi Iwata, Daigo Sawaki, Yumiko Hosoya, Jiro Ando, Toshiya Kojima, Yu Shimizu, Gaku Oguri …

Circulation journal : official journal of the Japanese Circulation Society 80(2) 538-40 2016年

もっとみる

MISC

KLF6 Modulates Aortic Aneurysm Formation by Balancing Between Inflammatory and TGF beta Signaling Pathways

Bo K. Son, Toru Suzuki, Daigo Sawaki, Kenichi Aizawa, Hong Zhan, Junichi Ishida, Takayoshi Matsumura, Ryozo Nagai

CIRCULATION 126(21) 2012年11月
Kruppel-like Factor 6 Promotes Obesity and Glucose Intolerance Through Adipocyte Differentiation

Junichi Ishida, Toru Suzuki, Kenichi Aizawa, Daigo Sawaki, Takayoshi Matsumura, Scott L. Friedman, Ryozo Nagai

CIRCULATION 126(21) 2012年11月
Cardiomyocyte Regulates Cardiac Fibrosis through Cell to Cell Interaction Mediated by KLF6

Daigo Sawaki, Toru Suzuki, Kenichi Aizawa, Takayoshi Matsumura, Yoshiko Munemasa, Junichi Ishida, Scott Friedman, Ryozo Nagai

CIRCULATION 126(21) 2012年11月
Klf5 Mediates a New Regulatory Pathway of Pathologic Vascular Injury Through DNA Double-Strand Break/Repair System

Kenichi Aizawa, Toru Suzuki, Hong Zhan, Daigo Sawaki, Junichi Ishida, Takayoshi Mastumura, Ryozo Nagai

CIRCULATION 124(21) 2011年11月
KLF6 Modulates Recruitment and Polarization of Inflammatory Cells Through Cardiomyocytes in Initiation of Cardiac Fibrosis

Daigo Sawaki, Toru Suzuki, Kenichi Aizawa, Takayoshi Matsumura, Yoshiko Munemasa, Junichi Ishida, Scott L. Fridman, Ryozo Nagai

CIRCULATION 124(21) 2011年11月
Kruppel-Like Factor 6 (KLF6) Regulates Obesity and Glucose Intolerance

Junichi Ishida, Toru Suzuki, Kenichi Aizawa, Daigo Sawaki, Takayoshi Matsumura, Scott L. Friedman, Ryozo Nagai

CIRCULATION 124(21) 2011年11月
衝心脚気と判明した治療抵抗性急性左心不全の1例

清水悠, 朝田一生, 山本幸, 多田祐子, 山形研一郎, 東邦康智, 細谷弓子, 高橋政夫, 澤城大悟, 岩田洋 …

ICUとCCU 35(10) 853-853 2011年10月査読有り
ベアメタルステントと比較した急性冠動脈症候群の患者における薬物溶出ステント後の1年臨床転帰

KIYOSUE Arihiro, ANDO Jiro, TANAKA Tomofumi, HASUMI Eriko, HIGASHIKUNI Yasutomi, KIMURA Kohichi, SAWAKI Daigo, TAKAHASHI Masao, IWATA Hiroshi, FUJITA Hideo …

日本心血管インターベンション治療学会抄録集 20th 2011年
Change in Levels Of B-Type Natriuretic Peptide (BNP) During Follow up Predicts in Stent Restenosis After Drug-Eluting Stent (DES) Implantation

Eriko Hasumi, Hiroshi Iwata, Takahide Kohro, Jiro Ando, Daigo Sawaki, Masao Takahashi, Hideo Fujita, Yasunobu Hirata, Ryozo Nagai

CIRCULATION 122(21) 2010年11月
Kruppel-like Factor 6 is a Key Transcription Factor in Adipocyte Differentiation

Junichi Ishida, Toru Suzuki, Kenichi Aizawa, Daigo Sawaki, Takayoshi Matsumura, Ryozo Nagai

CIRCULATION 120(18) S446-S446 2009年11月
OE-258 Kruppel-like Factor 6 is a Key Transcription Factor That Controls Cardiac Fibrosis(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Sawaki Daigo, Suzuki Toru, Aizawa Kenichi, Matsumura Takayoshi, Kada Nanae, Mizuno Yoshiko, Munemasa Yoshiko, Friedman Scott, Nagai Ryozo

Circulation journal : official journal of the Japanese Circulation Society 72 245 2008年3月1日
OE-173 A novel pathogenic pathway of DNA damage response as mediated by KLF5 and its transcriptional complexes in the cardiovasculature(Molecular biology, vascular(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Aizawa Kenichi, Suzuki Toru, Hong Zhan, Kada Nanae, Sawaki Daigo, Matsumura Takayoshi, Nagai Ryozo

Circulation journal : official journal of the Japanese Circulation Society 72 223 2008年3月1日
PE-165 Acyclic Retinoid Inhibits Vascular Remodeling by regulating KLF5(Cardiovascular pharmacology, basic/clinical(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Kada Nanae, Suzuki Toru, Aizawa Kenichi, Matsumura Takayoshi, Sawaki Daigo, Nagi Ryozo

Circulation journal : official journal of the Japanese Circulation Society 72 401 2008年3月1日
Proteome analysis of a regulatory pathway of pathologic vascular injury as mediated by KLF5 and its transcriptional complexes

Kenichi Aizawa, Toru Suzuki, Takayoshi Mastumura, Nanae Kada, Daigo Sawaki, Hong Zhan, Ryozo Nagai

CIRCULATION 116(16) 2-2 2007年10月
Kruppel-like factor 5 promotes vascular remodeling in a biphasic manner by inhibiting vascular smooth muscle cell apoptosis and stimulating cell growth

Daigo Sawaki, Toru Suzuki, Kenichi Aizawa, Takayoshi Matsumura, Nanae Kada, Yoshiko Mizuno, Yoshilko Munemasa, Ryozo Nagai

CIRCULATION 116(16) 44-45 2007年10月
OE-008 Cellular Proteomic Approach to Identify Transforming Growth Factor (TGF)-beta Induced DNA and/or RNA-binding Factors(Molecular biology, vascular-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Matsumura Takayoshi, Suzuki Toru, Aizawa Kenichi, Mizuno Yoshiko, Kada Nanae, Munemasa Yoshiko, Sawaki Daigo, Nagai Ryozo

Circulation journal : official journal of the Japanese Circulation Society 71 154 2007年3月1日
OE-183 Kruppel-like Factor 5 Directly Stimulates Cell Growth in Vascular Lesions(Vascular smooth muscle-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Sawaki Daigo, Suzuki Toru, Aizawa Kenichi, Matsumura Takayoshi, Kada Nanae, Mizuno Yoshiko, Munemasa Yoshiko, Nagai Ryouzou

Circulation journal : official journal of the Japanese Circulation Society 71 197 2007年3月1日
OE-009 Modulation of Ubiquitin-proteasomal Degradation of KLF5 Influences Vascular Remodeling(Molecular biology, vascular-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Sawaki Daigo, Suzuki Toru, Aizawa Kenichi, Matsumura Takayoshi, Kada Nanae, Mizuno Yoshiko, Munemasa Yoshiko, Nagai Ryouzou

Circulation journal : official journal of the Japanese Circulation Society 71 154 2007年3月1日
OJ-259 Acyclic Retinoid Inhibits Neointima Formation through Retinoic Acid Receptor Beta-induced Apoptosis(Cardiovascular pharmacology, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Kada Nanae, Suzuki toru, Aizawa Kenichi, Matsumura Takayoshi, Takeda Norifumi, Sawaki Daigo, Nagai Ryozo

Circulation journal : official journal of the Japanese Circulation Society 71 318 2007年3月1日
OE-048 Angiotensin II Activates the DNA Damage Response through Nitric Oxide in Vascular Endothelial Cells(Cardiac hypertrophy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Aizawa Kenichi, Suzuki Toru, Sawaki Daigo, Matsumura Takayoshi, Kada Nanae, Nagai Ryozo

Circulation journal : official journal of the Japanese Circulation Society 71 163 2007年3月1日

もっとみる

共同研究・競争的資金等の研究課題

骨髄老化による心血管疾患増悪機序の解明

日本学術振興会科学研究費助成事業基盤研究(C) 2024年4月 - 2027年3月

松村貴由, 岩田洋, 澤城大悟
マクロファージ細胞老化と極性変化に着目した抗腫瘍治療法の開発

日本学術振興会科学研究費助成事業基盤研究(C) 2024年4月 - 2027年3月

澤城大悟, 松村貴由
NADHを標的とした新たな心臓線維化治療法の開発

日本学術振興会科学研究費助成事業基盤研究(C) 2022年4月 - 2025年3月

砂河孝行, 澤城大悟
多次元質量分析による大動脈疾患のメタボロームバイオマーカー解析

日本学術振興会科学研究費助成事業基盤研究(C) 2021年4月 - 2024年3月

冨田翔大, 相澤健一, 澤城大悟, 木村夏花
心筋マクロファージの細胞老化に着目したHFｐEF病態解明と治療法開発

日本学術振興会科学研究費助成事業基盤研究(C) 2021年4月 - 2024年3月

澤城大悟, 冨田翔大, 相澤健一, 木村夏花
プロテオスタシス破綻に基づく心アミロイドーシスの理解と革新的診断法開発

日本学術振興会科学研究費助成事業挑戦的研究(萌芽) 2021年7月 - 2023年3月

相澤健一, 澤城大悟, 原田顕治, 木村夏花
平滑筋ミオシン変異による家族性大動脈解離の分子機構解明と治療法開発

日本学術振興会科学研究費助成事業研究活動スタート支援 2020年9月 - 2023年3月

澤城大悟
大動脈疾患での転写因子KLF6を軸とした病態機構解明と治療法の開発

日本学術振興会科学研究費助成事業若手研究(B) 2011年 - 2012年

澤城大悟, 鈴木亨, 相澤健一, 松村貴由, 石田純一, 孫輔卿, 永井良三
心血管・代謝疾患における転写因子KLF6を標的とした治療法の開拓

日本学術振興会科学研究費助成事業若手研究(B) 2009年 - 2010年

澤城大悟