Hiroshi Tsuda

Profile Information

Affiliation: Associate Medical Director, Clinical Development, Biogen
: Visiting Professor, Department of Neurology, Toho University
: Visiting Lecturer, Department of Neurology, Juntendo University
: Visiting Professor, University Hospital Clinical Research,Innovation and Education Center, Tohoku University

Researcher number: 00792095
J-GLOBAL ID: 201901004478764465
researchmap Member ID: B000375397

Research Areas

Life sciences / Neurology /

Papers

A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy.

Makoto Hideshima, Goichi Beck, Misaki Yamadera, Yuichi Motoyama, Kensuke Ikenaka, Keita Kakuda, Hiroshi Tsuda, Seiichi Nagano, Harutoshi Fujimura, Eiichi Morii, Shigeo Murayama, Hideki Mochizuki

Neuropathology : official journal of the Japanese Society of Neuropathology, 40(2) 191-195, Apr, 2020
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

Hideki Hayakawa, Rie Nakatani, Kensuke Ikenaka, Cesar Aguirre, Chi-Jing Choong, Hiroshi Tsuda, Seiichi Nagano, Masato Koike, Takeshi Ikeuchi, Masato Hasegawa, Stella M Papa, Yoshitaka Nagai, Hideki Mochizuki, Kousuke Baba

Movement disorders : official journal of the Movement Disorder Society, 35(2) 256-267, Feb, 2020
MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.

Taiki Yabumoto, Fumiaki Yoshida, Hideaki Miyauchi, Kousuke Baba, Hiroshi Tsuda, Kensuke Ikenaka, Hideki Hayakawa, Nozomu Koyabu, Hiroki Hamanaka, Stella M Papa, Masayuki Hirata, Hideki Mochizuki

Journal of neuroscience methods, 322 23-33, Jul 1, 2019
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.

Takuya Uehara, Chi-Jing Choong, Masayuki Nakamori, Hideki Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, Kousuke Baba, Tetsuya Nagata, Takanori Yokota, Hiroshi Tsuda, Satoshi Obika, Hideki Mochizuki

Scientific reports, 9(1) 7567-7567, May 21, 2019
Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.

Keita Kakuda, Kensuke Ikenaka, Katsuya Araki, Masatomo So, César Aguirre, Yuta Kajiyama, Kuni Konaka, Kentaro Noi, Kousuke Baba, Hiroshi Tsuda, Seiichi Nagano, Takuma Ohmichi, Yoshitaka Nagai, Takahiko Tokuda, Omar M A El-Agnaf, Hirotsugu Ogi, Yuji Goto, Hideki Mochizuki

Scientific reports, 9(1) 6001-6001, Apr 12, 2019
Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response.

Frédérique Larroquette, Lesley Seto, Perrine L Gaub, Brishna Kamal, Deeann Wallis, Roxanne Larivière, Joanne Vallée, Richard Robitaille, Hiroshi Tsuda

Human molecular genetics, 24(22) 6515-29, Nov 15, 2015 Peer-reviewed
The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.

Amina Moustaqim-Barrette, Yong Q Lin, Sreeparna Pradhan, Gregory G Neely, Hugo J Bellen, Hiroshi Tsuda

Human molecular genetics, 23(8) 1975-89, Apr 15, 2014 Peer-reviewed
Drosophila Vap-33 is required for axonal localization of Dscam isoforms.

Zhen Yang, Sung Un Huh, J Michelle Drennan, Hitesh Kathuria, Juan S Martinez, Hiroshi Tsuda, Mark C Hall, James C Clemens

The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(48) 17241-50, Nov 28, 2012 Peer-reviewed
Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

Sung Min Han, Hiroshi Tsuda, Youfeng Yang, Jack Vibbert, Pauline Cottee, Se-Jin Lee, Jessica Winek, Claire Haueter, Hugo J Bellen, Michael A Miller

Developmental cell, 22(2) 348-62, Feb 14, 2012 Peer-reviewed
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.

Miguel Mitne-Neto, Marcela Machado-Costa, Maria C N Marchetto, Mario H Bengtson, Claudio A Joazeiro, Hiroshi Tsuda, Hugo J Bellen, Helga C A Silva, Acary S B Oliveira, Monize Lazar, Alysson R Muotri, Mayana Zatz

Human molecular genetics, 20(18) 3642-52, Sep 15, 2011 Peer-reviewed
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.

Hugo J Bellen, Chao Tong, Hiroshi Tsuda

Nature reviews. Neuroscience, 11(7) 514-22, Jul, 2010 Peer-reviewed
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.

Hiroshi Tsuda, Sung Min Han, Youfeng Yang, Chao Tong, Yong Qi Lin, Kriti Mohan, Claire Haueter, Anthony Zoghbi, Yadollah Harati, Justin Kwan, Michael A Miller, Hugo J Bellen

Cell, 133(6) 963-77, Jun 13, 2008 Peer-reviewed
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.

Hiroshi Tsuda, Hamed Jafar-Nejad, Akash J Patel, Yaling Sun, Hung-Kai Chen, Matthew F Rose, Koen J T Venken, Juan Botas, Harry T Orr, Hugo J Bellen, Huda Y Zoghbi

Cell, 122(4) 633-44, Aug 26, 2005 Peer-reviewed
Dorsalization of the neural tube by Xenopus tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm.

Hiroshi Tsuda, Noriaki Sasai, Mami Matsuo-Takasaki, Makoto Sakuragi, Yoshinobu Murakami, Yoshiki Sasai

Neuron, 33(4) 515-28, Feb 14, 2002 Peer-reviewed
Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways

J Nakatani, K Mizuseki, H Tsuda, S Nakanishi, Y Sasai

MECHANISMS OF DEVELOPMENT, 91(1-2) 81-89, Mar, 2000 Peer-reviewed
Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split

M Nishimura, F Isaka, M Ishibashi, K Tomita, H Tsuda, S Nakanishi, R Kageyama

GENOMICS, 49(1) 69-75, Apr, 1998 Peer-reviewed
Structure and promoter analysis of Math3 gene, a mouse homolog of Drosophila proneural gene atonal - Neural-specific expression by dual promoter elements

H Tsuda, K Takebayashi, S Nakanishi, R Kageyama

JOURNAL OF BIOLOGICAL CHEMISTRY, 273(11) 6327-6333, Mar, 1998 Peer-reviewed
Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal

K Takebayashi, S Yakahashi, C Yokota, H Tsuda, S Nakanishi, M Asashima, R Kageyama

EMBO JOURNAL, 16(2) 384-395, Jan, 1997 Peer-reviewed
[Cerebral blood flow and metabolism in Lafora disease].

Tsuda H, Katsumi Y, Nakamura M, Ikeda A, Fukuyama H, Kimura J, Shibasaki H

Rinsho shinkeigaku = Clinical neurology, 35(2) 175-179, Feb, 1995 Peer-reviewed

Misc.

Facial onset sensory and motor neuronopathy(FOSMN)の一例

中野智仁, 廣澤太輔, 石倉照之, 秀嶋信, 神野隼輝, 津田浩史, 佐々木勉, 長野清一, 望月秀樹

臨床神経学, 58(12) 790-790, Dec, 2018
野生型及び変異α synuclein凝集体の分子特性に関するin vitro及びin vivoでの比較検討

早川英規, 馬場孝輔, 池中建介, 仲谷利栄, Aguirre Cesar, 鐘其静, 津田浩史, 長野清一, 永井義隆, 池内健, 望月秀樹

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 12回 74-74, Jul, 2018
Mammalian/Drosophila ataxin-1, the protein causing spinocerebellar ataxia 1, interacts with Gfi-1/senseless proteins via the highly conserved AXH domain

AJ Patel, H Tsuda, H Jafar-Nejad, HJ Bellen, MF Rose, HY Zoghbi

NEUROLOGY, 66(5) 288-289, Mar, 2006

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