2007年
Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: Toward practical and green access to clopidogrel
Organic and Biomolecular Chemistry
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- ,
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- 巻
- 5
- 号
- 8
- 開始ページ
- 1175
- 終了ページ
- 1176
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/b703463f
Methyl (R)-o-chloromandelate ((R)-1), which is an intermediate for a platelet aggregation inhibitor named clopidogrel, was obtained in >99% ee by the asymmetric reduction of methyl o-chlorobenzoylformate (2) (up to 1.0 M) with recombinant E. coli overproducing a versatile carbonyl reductase. © The Royal Society of Chemistry.
- リンク情報
- ID情報
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- DOI : 10.1039/b703463f
- ISSN : 1477-0520
- PubMed ID : 17406715
- SCOPUS ID : 34047205385