2003年7月
Enhancement of the efficiency of the low temperature method for kinetic resolution of primary alcohols by optimizing the organic bridges in porous ceramic-immobilized lipase
Bulletin of the Chemical Society of Japan
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- 巻
- 76
- 号
- 7
- 開始ページ
- 1441
- 終了ページ
- 1446
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/bcsj.76.1441
For the enhancement of enantioselectivity and acceleration of the reaction rate in the lipase-catalyzed resolution of primary alcohols, the use of a very low reaction temperature (-30 °C) and an immobilized lipase on organic bridges-coated porous ceramic support was found to be highly effective. Furthermore, the structure of the organic bridges greatly influenced the temperature effect between in E and 1/T as well as the reaction rate. Among the organic bridges examined in the resolution of (±)-2-hydroxymethyl-1,4-benzodioxane, the 6-(2-methylpropanoyloxy)hexylsilanetrioxyl bridge was the best choice for both the E value and the reaction rate at -30 °C.
- リンク情報
- ID情報
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- DOI : 10.1246/bcsj.76.1441
- ISSN : 0009-2673
- SCOPUS ID : 0042662635