2012年6月
Total Synthesis of Thelephantin O, Vialinin A/Terrestrin A, and Terrestrins B-D
JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 77
- 号
- 11
- 開始ページ
- 5161
- 終了ページ
- 5166
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/jo300565s
- 出版者・発行元
- AMER CHEMICAL SOC
The first total synthesis of natural, unsymmetrical 2',3'-diacyloxy-p-terphenyls, thelephantin O (1) and terrestrins C and D (2 and 3, respectively), was achieved via a practical route which was also applicable to the synthesis of the symmetrical diesters vialinin A/terrestrin A. (4) and terrestrin B (5). Compounds 1-5 exhibited cytotoxicity against cancer cells (HepG2 and Caco2) with IC50 values of 13.6-26.7 mu mol/L.
- リンク情報
- ID情報
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- DOI : 10.1021/jo300565s
- ISSN : 0022-3263
- PubMed ID : 22571724
- Web of Science ID : WOS:000304682400032