2014年
Successful treatment of persistent MRSA bacteremia using high-dose daptomycin combined with rifampicin.
Internal medicine (Tokyo, Japan)
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- 巻
- 53
- 号
- 18
- 開始ページ
- 2159
- 終了ページ
- 63
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.53.2711
- 出版者・発行元
- JAPAN SOC INTERNAL MEDICINE
We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient's condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.
- リンク情報
- ID情報
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- DOI : 10.2169/internalmedicine.53.2711
- ISSN : 0918-2918
- eISSN : 1349-7235
- PubMed ID : 25224207
- Web of Science ID : WOS:000342348000024