2016
Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS).
Internal medicine (Tokyo, Japan)
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- Volume
- 55
- Number
- 13
- First page
- 1769
- Last page
- 74
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.2169/internalmedicine.55.6287
- Publisher
- JAPAN SOC INTERNAL MEDICINE
A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus ( HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
- Link information
- ID information
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- DOI : 10.2169/internalmedicine.55.6287
- ISSN : 0918-2918
- eISSN : 1349-7235
- Pubmed ID : 27374681
- Web of Science ID : WOS:000379216100017