Papers

International journal
Aug, 2021

Effectiveness of supplemental oral calcium drink in preventing citrate-related adverse effects in peripheral blood progenitor cell collection.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • Keiko Fujii
  • Nobuharu Fujii
  • Takumi Kondo
  • Toshiharu Mitsuhashi
  • Makoto Nakamura
  • Keisuke Seike
  • Yasuhisa Sando
  • Maiko Kimura
  • Masayuki Matsuda
  • Shuntaro Ikegawa
  • Hiroyuki Sugiura
  • Fumio Otsuka
  • Yoshinobu Maeda
  • Display all

Volume
60
Number
4
First page
103147
Last page
103147
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.transci.2021.103147
Publisher
PERGAMON-ELSEVIER SCIENCE LTD

Peripheral blood progenitor cells (PBPCs) are a predominant graft source in allogeneic hematopoietic cell transplantation. Citrate-induced hypocalcemia remains the most frequent side effect of PBPC apheresis. Although the method for preventing severe adverse events is established, more efficient prophylaxis is required so that volunteer donors can donate PBPCs without pain and anxiety. We studied 80 healthy donors who underwent PBPC harvest between February 2014 and June 2020. Of these, 23 donors who underwent apheresis between February 2014 and December 2015 received only the standard prophylaxis of intravenous calcium gluconate. Oral calcium drinks were provided to 57 donors who underwent apheresis from January 2016 to June 2020 to supplement intravenous calcium gluconate prophylaxis. The ionized calcium (ICa) levels at multiple time intervals and the hypocalcemic symptoms were evaluated. Oral supplementation with a calcium drink maintained significantly higher ICa levels. Analysis using the inverse probability weighted regression adjustment method suggested that calcium drinks reduced the frequency of citrate-related reactions by 39.2 %. Administering a prophylactic oral calcium drink before apheresis with intravenous administration of calcium gluconate is promising to further reduce citrate-induced hypocalcemia in volunteer donors.

Link information
DOI
https://doi.org/10.1016/j.transci.2021.103147
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33931360
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000686760900007&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.transci.2021.103147
  • ISSN : 1473-0502
  • eISSN : 1878-1683
  • Pubmed ID : 33931360
  • Web of Science ID : WOS:000686760900007

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