2016年10月
Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis.
PLoS pathogens
- ,
- ,
- 巻
- 12
- 号
- 10
- 開始ページ
- e1005845
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.ppat.1005845
- 出版者・発行元
- PUBLIC LIBRARY SCIENCE
Amebiasis is caused by Entamoeba histolytica infection and can produce a broad range of clinical signs, from asymptomatic cases to patients with obvious symptoms. The current epidemiological and clinical statuses of amebiasis make it a serious public health problem worldwide. The Entamoeba life cycle consists of the trophozoite, the causative agent for amebiasis, and the cyst, the form responsible for transmission. These two stages are connected by "encystation" and "excystation." Hence, developing novel strategies to control encystation and excystation will potentially lead to new measures to block the transmission of amebiasis by interrupting the life cycle of the causative agent. Here, we highlight studies investigating encystation using inhibitory chemicals and categorize them based on the molecules inhibited. We also present a perspective on new strategies to prevent the transmission of amebiasis.
- リンク情報
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- DOI
- https://doi.org/10.1371/journal.ppat.1005845
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27764256
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072687
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000387666900005&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1371/journal.ppat.1005845
- ISSN : 1553-7366
- eISSN : 1553-7374
- PubMed ID : 27764256
- PubMed Central 記事ID : PMC5072687
- Web of Science ID : WOS:000387666900005