論文

査読有り 筆頭著者 国際誌
2010年2月

Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons

JOURNAL OF NEUROSCIENCE
  • Goichi Miyoshi
  • ,
  • Jens Hjerling-Leffler
  • ,
  • Theofanis Karayannis
  • ,
  • Vitor H. Sousa
  • ,
  • Simon J. B. Butt
  • ,
  • James Battiste
  • ,
  • Jane E. Johnson
  • ,
  • Robert P. Machold
  • ,
  • Gord Fishell

30
5
開始ページ
1582
終了ページ
1594
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.4515-09.2010
出版者・発行元
SOC NEUROSCIENCE

By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE). Interestingly, compared with medial ganglionic eminence (MGE)-derived cortical interneuron populations, the initiation [embryonic day 12.5 (E12.5)] and peak production (E16.5) of interneurons from this embryonic structure occurs 3 d later in development. Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate. In contrast to previous estimates, CGE-derived interneurons are both considerably greater in number (similar to 30% of all cortical interneurons) and diversity (comprised by at least nine distinct subtypes). Furthermore, we found that a large proportion of CGE-derived interneurons, including the neurogliaform subtype, express the glycoprotein Reelin. In fact, most CGE-derived cortical interneurons express either Reelin or vasoactive intestinal polypeptide. Thus, in conjunction with previous studies, we have now determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes.

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.4515-09.2010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20130169
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826846
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000274246700003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.4515-09.2010
  • ISSN : 0270-6474
  • PubMed ID : 20130169
  • PubMed Central 記事ID : PMC2826846
  • Web of Science ID : WOS:000274246700003

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