2007年7月
Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic olig2-expressing precursors
JOURNAL OF NEUROSCIENCE
- ,
- ,
- ,
- 巻
- 27
- 号
- 29
- 開始ページ
- 7786
- 終了ページ
- 7798
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1523/JNEUROSCI.1807-07.2007
- 出版者・発行元
- SOC NEUROSCIENCE
Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.
- リンク情報
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- DOI
- https://doi.org/10.1523/JNEUROSCI.1807-07.2007
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17634372
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672881
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000248177900017&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1523/JNEUROSCI.1807-07.2007
- ISSN : 0270-6474
- eISSN : 1529-2401
- PubMed ID : 17634372
- PubMed Central 記事ID : PMC6672881
- Web of Science ID : WOS:000248177900017