論文

査読有り
2005年3月

Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis

ANTIOXIDANTS & REDOX SIGNALING
  • Y Takahashi
  • ,
  • H Zhu
  • ,
  • T Yoshimoto

7
3-4
開始ページ
425
終了ページ
431
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/ars.2005.7.425
出版者・発行元
MARY ANN LIEBERT, INC

Oxidative modification of low-density lipoprotein (LDL) is one of the critical steps for the development of atherosclerosis. Accumulating studies have indicated that 12/15-lipoxygenase highly expressed in macrophages plays an essential role in the oxidation of circulating LDL. It has been demonstrated that LDL needs to bind the LDL receptor-related protein (LRP), a cell-surface receptor, prior to its oxidation by 12/15-lipoxygenase expressed in macrophages. LRP is suggested to mediate the selective transfer of cholesteryl ester in LDL to the plasma membrane of macrophages without endocytosis and degradation of the LDL particle. At the same time, binding of LDL to LRP translocates the 12/15-lipoxygenase from the cytosol to the plasma membrane. It is also demonstrated that 5-lipoxygenase localized in macrophages generates leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues and contribute to lesion development. Therefore, the inhibition of these lipoxygenases may be effective in the prevention and treatment of the inflammatory diseases.

リンク情報
DOI
https://doi.org/10.1089/ars.2005.7.425
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15706089
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000227319200012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1089/ars.2005.7.425
  • ISSN : 1523-0864
  • eISSN : 1557-7716
  • PubMed ID : 15706089
  • Web of Science ID : WOS:000227319200012

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