Shimomura Hirofumi

Profile Information

Affiliation: 主任技師（獣医師）, 熊本県宇城地域振興局衛生環境課

Degree: Doctor(Medicine)(Jichi Medical University)

J-GLOBAL ID: 200901042522030743
researchmap Member ID: 5000045793

Research Interests

Research Areas

Life sciences / Bioorganic chemistry / Biochemistry of Lipids
Nanotechnology/Materials / Structural/physical organic chemistry / Biochemistry of Lipids
Life sciences / Pharmaceuticals - chemistry and drug development / Antibacterial medicines, antitumor medicines
Life sciences / Bacteriology / Helicobacter pylori, Burkholderia cepacia

Research History

Apr, 2022 - Present

熊本県宇城振興局衛生環境課
Jun, 2020 - Mar, 2022

部門長, オルガノイド研究部門, 株式会社KBBM
Oct, 2019 - May, 2020

ビッグベア動物病院 (非常勤獣医師)
Apr, 2016 - Apr, 2019

Professor, Shokei University
Apr, 2015 - Mar, 2016

Jichi Medical University
Apr, 2009 - Mar, 2015

Jichi Medical University
Apr, 2002 - Mar, 2009

Jichi Medical University
Apr, 2001 - Mar, 2002

獣医師, 家畜診療所, 株式会社ジャパンファーム養豚事業本部
Apr, 1994 - Mar, 1997

獣医師, 畜産事業推進室, JA熊本経済連

Awards

Jun, 2018

最優秀ポスター賞, 極めて選択的にピロリ菌を殺菌する新規抗菌薬の研究・開発, 新規素材探索研究会

鰐渕清史, 伊原聖人, 下村裕史, 庄司満, 高橋孝志
Feb, 2004

Scientific Award, Identification of the functional protein that is strongly detected in coccoid forms of Helicobacter pylori, Japan-Korea Joint Meeting on Helicobacter Infection

Hirofumi Shimomura

Papers

Aspects for development of novel antibacterial medicines using a vitamin D3 decomposition product in Helicobacter pylori infection

Kiyofumi Wanibuchi, Kouichi Hosoda, Avarzed Amgalanbaatar, Masato Ihara, Motoki Takezawa, Yuki Sakai, Hisashi Masui, Mitsuru Shoji, Shunji Hayashi, Hirofumi Shimomura

The Journal of Antibiotics, Sep 1, 2023 Peer-reviewedCorresponding author
The chronic and acute toxicity of traditional medicines containing Terminalia chebula

ARONGQIQIGE, Gerelmaa Enebish, Wang Song, Wei Cheng Xi, Anuujin Gantumur, Oyunbaatar Altanbayar, Hirofumi Shimomura, Battogtokh Chimeddorj, Batnairamdal Chuluun, Avarzed Amgalanbaatar

Journal of Pharmacopuncture, 26(1) 18-26, Mar 31, 2023 Peer-reviewed
A novel role of catalase in cholesterol uptake of Helicobacter pylori

Kouichi Hosoda, Kiyofumi Wanibuchi, Avarzed Amgalanbaatar, Mitsuru Shoji, Shunji Hayashi, Hirofumi Shimomura

Steroids, Dec, 2022 Peer-reviewedCorresponding author
A short review, effect of dimethyl-β-cyclodextrin on the interaction between Helicobacter pylori and steroidal compounds

Kiyofumi Wanibuchi, Kouichi Hosoda, Avarzed Amgalanbaatar, Yoshikazu Hirai, Mitsuru Shoji, Hirofumi Shimomura

Heliyon, 7, Apr, 2021 Peer-reviewedCorresponding author
Unique responses of Helicobacter pylori to exogenous hydrophobic compounds

Hirofumi Shimomura, Kiyofumi Wanibuchi, Kouichi Hosoda, Avarzed Amgalanbaatar, Hisashi Masui, Takashi Takahashi, Yoshikazu Hirai

Chemistry and Physics of Lipids, 229 104908-104908, Jul, 2020 Peer-reviewedLead authorCorresponding author
Antibacterial effect of indene on Helicobacter pylori correlates with specific interaction between its compound and dimyristoyl-phosphatidylethanolamine

Kiyofumi Wanibuchi, Motoki Takezawa, Kouichi Hosoda, Avarzed Amgalanbaatar, Kentaro Tajiri, Yuki Koizumi, Sakura Niitsu, Hisashi Masui, Yuki Sakai, Mitsuru Shoji …

Chemistry and Physics of Lipids, 227 104871-104871, 2020 Peer-reviewedLast authorCorresponding author
Erratum: Author Correction: Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella Enterica subsp. enterica serovar Enteritidis in Chickens.

Yuuichi Ishida, Eishi Sakai, Katsuo Sato, Einori Sugiyama, Kazuyuki Mima, Akira Taneno, Hirofumi Shimomura, Longzhu Cui, Yoshikazu Hirai

Food safety (Tokyo, Japan), 7(2) 58-59, Jun, 2019
Correlation between Helicobacter pylori Infection and Gastric Atrophy Examined in the Sera of Mongolian People

Amgalanbaatar A, Shimomura H, Sugano K, Bira TO, Okamoto H, Hirai Y

Gastrointest Diord, 1 241-252, 2019 Peer-reviewed
Indene Compounds Synthetically Derived from Vitamin D Have Selective Antibacterial Action on Helicobacter pylori

Kiyofumi Wanibuchi, Kouichi Hosoda, Masato Ihara, Kentaro Tajiri, Yuki Sakai, Hisashi Masui, Takashi Takahashi, Yoshikazu Hirai, Hirofumi Shimomura

Lipids, 53(4) 393-401, Apr 1, 2018 Peer-reviewedCorresponding author
Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella enterica subsp. enterica serovar Enteritidis in Chickens

Ishida Y, Sakai E, Sato K, Sugiyama E, Mima K, Tanino A, Shimomura H, Cui L, Hirai Y

Food Safety, 6 151-155, 2018 Peer-reviewed
Phosphatidylethanolamine, but not Phosphatidylglycerol-Cardiolipin, Isolated from Two Species of Helicobacter Binds Cholesterol over Cholesteryl Ester

Avarzed Amgalanbaatar, Kouichi Hosoda, Hirofumi Shimomura

LIPIDS, 50(8) 799-804, Aug, 2015 Peer-reviewedCorresponding author
Identification and characterization of a vitamin D-3 decomposition product bactericidal against Helicobacter pylori

Kouichi Hosoda, Hirofumi Shimomura, Kiyofumi Wanibuchi, Hisashi Masui, Avarzed Amgalanbaatar, Shunji Hayashi, Takashi Takahashi, Yoshikazu Hirai

SCIENTIFIC REPORTS, 5, Mar, 2015 Peer-reviewedCorresponding author
Antibacterial activity of a novel synthetic progesterone species carrying a linoleic acid molecule against Helicobacter pylori and the hormonal effect of its steroid on a murine macrophage-like cell line

Avarzed Amgalanbaatar, Hirofumi Shimomura, Kouichi Hosoda, Shunji Hayashi, Kenji Yokota, Yoshikazu Hirai

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 140 17-25, Mar, 2014 Peer-reviewedCorresponding author
Detoxification of 7-Dehydrocholesterol Fatal to Helicobacter pylori Is a Novel Role of Cholesterol Glucosylation

Hirofumi Shimomura, Kouichi Hosoda, David J. Mcgee, Shunji Hayashi, Kenji Yokota, Yoshikazu Hirai

JOURNAL OF BACTERIOLOGY, 195(2) 359-367, Jan, 2013 Peer-reviewedLead authorCorresponding author
Phosphatidylethanolamine of Helicobacter pylori Functions as a Steroid-Binding Lipid in the Assimilation of Free Cholesterol and 3 beta-Hydroxl Steroids into the Bacterial Cell Membrane

Hirofumi Shimomura, Kouichi Hosoda, Shunji Hayashi, Kenji Yokota, Yoshikazu Hirai

JOURNAL OF BACTERIOLOGY, 194(10) 2658-2667, May, 2012 Peer-reviewedLead authorCorresponding author
Steroid hormones as bactericidal agents to Helicobacter pylori

Kouichi Hosoda, Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Yoshikazu Hirai

FEMS MICROBIOLOGY LETTERS, 318(1) 68-75, May, 2011 Peer-reviewedCorresponding author
Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori

Hirofumi Shimomura, Kouichi Hosoda, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai

FEMS MICROBIOLOGY LETTERS, 301(1) 84-94, Dec, 2009 Peer-reviewedLead authorCorresponding author
Anabolic utilization of steroid hormones in Helicobacter pylori

Kouichi Hosoda, Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai

FEMS MICROBIOLOGY LETTERS, 297(2) 173-179, Aug, 2009 Peer-reviewedCorresponding author
Conversion of flavodoxin from holoenzyme to apoprotein during growth phase changes in Helicobacter pylori

Hirofumi Shimomura, Shunji Hayashi, Kenji Yokota, Keiji Oguma, Yoshikazu Hirai

JOURNAL OF BACTERIOLOGY, 189(13) 4960-4963, Jul, 2007 Peer-reviewedLead authorCorresponding author
Alteration in the composition of cholesteryl glucosides and other lipids in Helicobacter pylori undergoing morphological change from spiral to coccoid form

H Shimomura, S Hayashi, K Yokota, K Oguma, Y Hirai

FEMS MICROBIOLOGY LETTERS, 237(2) 407-413, Aug, 2004 Peer-reviewedLead authorCorresponding author

Misc.

Gastric Helicobacterに属する菌種

下村裕史

Helicobacter Res, 20 245-251, 2016 Lead authorCorresponding author
Interaction of Helicobacter pylori cell membrane with non-esterified cholesterol and other steroids

Shimomura H, Hosoda K, Hirai Y

OJMM, 3 70-79, 2013 Peer-reviewedLead authorCorresponding author
Helicobacter pyloriと胃癌

下村裕史, 林俊治, 平井義一

臨床と微生物, 38 195-202, 2011 Lead authorCorresponding author
H. pyloriの薬剤耐性獲得機構

林俊治, 下村裕史, 平井義一

medicina, 47 1804-1807, 2010
Helicobacter pylori感染と免疫応答

林俊治, 下村裕史, 平井義一

臨床検査, 54 151-157, 2010
Helicobacter cinaediの性状と病原性

下村裕史, 細田浩一, 林俊治, 平井義一

Helicobacter Res, 14 110-114, 2010 Lead authorCorresponding author
新しい “Helicobacter属” について教えてください

下村裕史, 林俊治, 平井義一

Helicobacter Res, 13 63-65, 2009 Lead authorCorresponding author
Non-pylori Helicobacterに関する最新情報

林俊治, 下村裕史, 平井義一

日本臨床, 67 2271-2278, 2009
発色試薬添加Helicobacter pylori分離培地の比較検討

林俊治, 太田英孝, 林芳和, 下村裕史, 平井義一

臨床と微生物, 34(4) 351-354, 2007
Helicobacter pyloriの細菌学的特徴として最近話題の「コレステリールグルコシドによる免疫回避機構」について教えて下さい

下村裕史, 林俊治, 平井義一

Helicobacter Res, 11 105-108, 2007 Lead authorCorresponding author
Helicobacter pyloriの細菌学について

林俊治, 横田憲治, 下村裕史, 小熊恵二, 平井義一

日本ヘリコバクター学会誌, 8 15-21, 2006
H. cinaedi, H. fenneliae, H. pullorumの性状と病原性

平井義一, 下村裕史, 林俊治, 横田憲治, 小熊恵二

臨床と微生物, 32 79-84, 2005
図解：Helicobacter pyloriの糖脂質の分析法

平井義一, 下村裕史, 林俊治, 横田憲治, 小熊恵二

Helicobacter Res, 7 2-9, 2003
院内の水系汚染対策

林俊治, 下村裕史, 熊丸貴俊, 平井義一

感染と抗菌薬, 5 418-420, 2002
H. cinaedi, H. fenneliae, H. pullorumの性状と病原性

平井義一, 林俊治, 下村裕史, 横田憲治, 小熊恵二

Helicobacter Res, 5 117-123, 2001
Association of Helicobacter pylori with gastroduodenal diseases

Y Hirai, S Hayashi, H Shimomura, K Oguma, K Yokota

JAPANESE JOURNAL OF INFECTIOUS DISEASES, 52(5) 183-197, Oct, 1999

Books and Other Publications

Gastritis-New Approach and Treatment

Wanibuchi K, Masui H, Takahashi T, Shimomura H (Role: Joint author, Development of a novel antibacterial medicine that targets a characteristic lipid of the cell membranes of Helicobacter pylori)

IntechOpen, 2019
Steroids-clinical aspect

Shimomura H (Role: Joint author, Relationship between steroid hormones and Helicobacter pylori)

InTech, 2011

Presentations

種々の疎水性化合物に対するピロリ菌の膜応答性

下村裕史

くまもと食品科学研究会第55回研究会, 2017 Invited
日本人の食生活を脅かす食中毒

下村裕史

平成29年度尚絅講座人間探求-暮らしを見つめ直す-, 2017
Membranal responses of Helicobacter pylori to various lipids

下村裕史

第18回北里微生物アカデミー研究集会, 2015 Invited
Steroid hormones as bactericidal agents to Helicobacter pylori

Hosoda K, Shimomura H, Hayashi S, Hirai Y

XIII International Congress of Bacteriology and Applied Microbiology, 2011
Anabolic utilization of steroid hormones in Helicobacter pylori

Hosoda K, Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y

15th International Workshop on Campylobacter, Helicobacter, and Related Organisms, 2009
ヘリコバクター・ピロリの外膜脂質バリアー強化に重要なコレステロール吸収

下村裕史, 細田浩一, 林俊治, 平井義一

第15回日本ヘリコバクター学会, 2009
これまで知られていないヘリコバクター属細菌の無γグロブリン血症患者からの分離

下村裕史, 林俊治, 平井義一

第14回日本ヘリコバクター学会, 2008
Conversion of flavodoxin from holoenzyme to apoprotein during growth phase changes in Helicobacter pylori

Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y

ASM General 107th Meeting, 2007
アモキシシリンの予防的投与による豚胸膜肺炎の防遏効果

下村裕史, 林俊治, 平井義一

第79回日本細菌学会総会, 2006
Treatment except for antibiotic therapy; recent trends of integrative medicine for the treatment of H. pylori infection in Japan

Hirai Y, Hayashi S, Shimomura H

The 4th Annual Conference of Japan-Korea Joint Meeting on Helicobacter Infection, 2005
Helicobacter pyloriにおけるフラボドキシン代謝経路の解析

下村裕史, 林俊治, 横田憲治, 小熊恵二, 平井義一

第78回日本細菌学会総会, 2005
Alteration in the composition of cholesteryl glucosides and other lipids in Helicobacter pylori undergoing morphological change from spiral to coccoid form

Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y

5th Western Pacific Helicobacter Congress, 2004
Identification of the functional protein that is strongly detected in coccoid forms of Helicobacter pylori

Shimomura H, Hayashi S, Yokota K, Oguma K, Hirai Y

The 3rd Annual Conference of Japan-Korea Joint Meeting on Helicobacter Infection, 2004
Combined effect of Tellimagrandin-I and amoxicillin against Helicobacter pylori

Hayashi S, Funatogawa K, Shimomura H, Yoshida T, Hatano T, Ito H, Hirai Y

The 3rd Annual Conference of Japan-Korea Joint Meeting on Helicobacter Infection, 2004
Helicobacter pyloriの球状体におけるflavodoxinの発現

下村裕史, 林俊治, 横田憲治, 小熊恵二, 平井義一

第76回日本細菌学会総会, 2003
Anti-Helicobacter pylori activities of polyphenols extracted from plants

Hayashi S, Funatogawa K, Shimomura H, Yoshida T, Hatano T, Ito H, Hirai Y

The 1st Annual Conference of Japan-Korea Joint Meeting on Helicobacter Infection, 2001
Burkholderia属細菌LPSによるエンドトキシン活性の発現

下村裕史, 松浦基博, 平井義一, 一色恭徳, 川原一芳

第46回毒素シンポジウム, 1999

Teaching Experience

Professional Memberships

Research Projects

Analysis of Flavodoxin in Helicobacter pylori

2002 - 2007

Industrial Property Rights

特許第63976959号抗ピロリ菌剤

下村裕史, 細田浩一, 平井義一, 高橋孝志, 鰐渕清史

Social Activities

細菌性食中毒

Lecturer

熊本県立熊本西高等学校, Oct 25, 2017
管理栄養士について

Lecturer

熊本県立小国高等学校, Sep 29, 2017

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

Social Activities

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