論文

査読有り
2016年

Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer

INTERNAL MEDICINE
  • Takeshi Kondo
  • Itsuro Endo
  • Yukari Ooguro
  • Kana Morimoto
  • Kiyoe Kurahashi
  • Sumiko Yoshida
  • Akio Kuroda
  • Ken-ichi Aihara
  • Munehide Matsuhisa
  • Masahiro Abe
  • Seiji Fukumoto
  • 全て表示

55
24
開始ページ
3623
終了ページ
3626
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.55.7359
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.55.7359
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27980263
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000390252600010&DestApp=WOS_CPL
ID情報
  • DOI : 10.2169/internalmedicine.55.7359
  • ISSN : 0918-2918
  • eISSN : 1349-7235
  • PubMed ID : 27980263
  • Web of Science ID : WOS:000390252600010

エクスポート
BibTeX RIS