2016年
Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
INTERNAL MEDICINE
- 巻
- 55
- 号
- 24
- 開始ページ
- 3623
- 終了ページ
- 3626
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.55.7359
- 出版者・発行元
- JAPAN SOC INTERNAL MEDICINE
A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.
- リンク情報
- ID情報
-
- DOI : 10.2169/internalmedicine.55.7359
- ISSN : 0918-2918
- eISSN : 1349-7235
- PubMed ID : 27980263
- Web of Science ID : WOS:000390252600010