Hiromi Kinoh

Profile Information

Affiliation: The University of Tokyo
: 客員研究員, 神経研究所, 独立行政法人国立精神・神経医療研究センター

Degree: 博士（医学）(Jun, 2002, 東京大学)

Other name(s) (e.g. nickname): Hayashita Hiromi
J-GLOBAL ID: 201401033119657400
researchmap Member ID: B000241382

External link: http://kaken.nii.ac.jp/d/r/60532728.ja.html

Research Interests

Research Areas

Research History

Oct, 2020 - Present

The Institute of Medical Science, The University of Tokyo
Sep, 2008 - Present

National Center of Neurology and Psychiatry
Sep, 2014 - Sep, 2020

Nippon Medical School
Mar, 2007 - Aug, 2008

Hiroshima University
Apr, 2002 - Feb, 2007

Juntendo University

Papers

Improved transduction of canine X-linked muscular dystrophy with rAAV9-microdystrophin via multipotent MSC pretreatment.

Hiromi Hayashita-Kinoh, Posadas-Herrera Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hironori Okada, Tomoko Chiyo, Shin'ichi Takeda, Takashi Okada

Molecular therapy. Methods & clinical development, 20 133-141, Mar 12, 2021
Enhanced cell survival and therapeutic benefits of IL-10-expressing multipotent mesenchymal stromal cells for muscular dystrophy.

Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin'ichi Takeda, Takashi Okada

Stem cell research & therapy, 12(1) 105-105, Feb 4, 2021
Dental pulp stem cells can improve muscle dysfunction in animal models of Duchenne muscular dystrophy.

Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Posadas Herrera Guillermo, Hiromi Hayashita-Kinoh, Yasunobu Maruoka, Aki Nakamura-Takahasi, Koichi Kimura, Shin'ichi Takeda, Takashi Okada

Stem cell research & therapy, 12(1) 78-78, Jan 25, 2021
Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery.

Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Yuko Katakai, Hiromi Hayashita-Kinoh, Chiaki Fujimoto, Shuhei Kameya, Hiroshi Takahashi, Takashi Okada

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 88(2) 103-108, 2021
rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates.

Akiko Ishii, Hironori Okada, Hiromi Hayashita-Kinoh, Jin-Hong Shin, Akira Tamaoka, Takashi Okada, Shin'ichi Takeda

Molecular therapy. Methods & clinical development, 18 44-49, Sep 11, 2020 Peer-reviewed
Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes.

Seiji Kuroda, Yoshitaka Miyagawa, Yuriko Sato, Motoko Yamamoto, Kumi Adachi, Hiromi Kinoh, William F Goins, Justus B Cohen, Joseph C Glorioso, Nobuhiko Taniai …

Molecular therapy. Methods & clinical development, 17 612-621, Jun 12, 2020 Peer-reviewed
Biodistribution Analysis of Transgene Expression from a Non-Cytotoxic Herpes Simplex Virus Based Vector

Miyagawa Yoshitaka, Maruyama Motoyo, Kuroda Seiji, Sakai Atsushi, Sato Yuriko, Kinoh Hiromi, Yamamoto Motoko, Cohen Justus B, Glorioso Joseph C, Okada Takashi

MOLECULAR THERAPY, 27(4) 196, Apr 22, 2019 Peer-reviewed
Intra-amniotic rAAV-mediated microdystrophin gene transfer improves canine X-linked muscular dystrophy and may induce immune tolerance.

Hayashita-Kinoh H, Yugeta N, Okada H, Nitahara-Kasahara Y, Chiyo T, Okada T, Takeda S

Molecular therapy : the journal of the American Society of Gene Therapy, Apr, 2015 Peer-reviewed
Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10.

Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Nishiyama A, Okada H, Takeda S, Okada T

Human molecular genetics, Aug, 2014 Peer-reviewed
DISRUPTION OF COMMON MARMOSET DYSTROPHIN mRNA TO GENERATE NON-HUMAN PRIMATE DMD MODEL

Hironori Okada, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Hirohiko Hohjoh, Yuko Nitahara-Kasahara, Takashi Okada, Shin'ichi Takeda

JOURNAL OF GENE MEDICINE, 16(7-8) 242-243, Jul, 2014 Peer-reviewed
Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9.

Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Baba Y, Watanabe S, Takeda S, Okada T

Molecular therapy. Nucleic acids, 2013 Peer-reviewed
Long-term engraftment of multipotent mesenchymal stromal cells that differentiate to form myogenic cells in dogs with Duchenne muscular dystrophy.

Nitahara-Kasahara Y, Hayashita-Kinoh H, Ohshima-Hosoyama S, Okada H, Wada-Maeda M, Nakamura A, Okada T, Takeda S

Molecular therapy : the journal of the American Society of Gene Therapy, Jan, 2012 Peer-reviewed
Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction.

Shin JH, Nitahara-Kasahara Y, Hayashita-Kinoh H, Ohshima-Hosoyama S, Kinoshita K, Chiyo T, Okada H, Okada T, Takeda S

Gene therapy, Sep, 2011 Peer-reviewed
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.

Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y

The Journal of biological chemistry, Apr, 2011 Peer-reviewed
Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.

Okada T, Nonaka-Sarukawa M, Uchibori R, Kinoshita K, Hayashita-Kinoh H, Nitahara-Kasahara Y, Takeda S, Ozawa K

Human gene therapy, Sep, 2009 Peer-reviewed
Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease.

Oizumi H, Hayashita-Kinoh H, Hayakawa H, Arai H, Furuya T, Ren YR, Yasuda T, Seki T, Mizuno Y, Mochizuki H

Neuroscience research, Jan, 2008 Peer-reviewed
The isolation of neural stem cells from the olfactory bulb of Parkinson's disease model.

Hayakawa H, Hayashita-Kinoh H, Nihira T, Seki T, Mizuno Y, Mochizuki H

Neuroscience research, Mar, 2007 Peer-reviewed
Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.

Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H

Biochemical and biophysical research communications, Mar, 2006 Peer-reviewed
Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase.

Komori K, Nonaka T, Okada A, Kinoh H, Hayashita-Kinoh H, Yoshida N, Yana I, Seiki M

FEBS letters, Jan, 2004 Peer-reviewed
Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth.

Hayashita-Kinoh H, Kinoh H, Okada A, Komori K, Itoh Y, Chiba T, Kajita M, Yana I, Seiki M

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Nov, 2001 Peer-reviewed

Misc.

Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment

Hiromi Hayashita-Kinoh, Posadas Herrera-Guillermo, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 30(4) 494-494, Apr, 2022
Anti-Inflammatory Properties of IL-10-Expressing Multipotent Mesenchymal Stromal Cells for Duchenne Muscular Dystrophy

Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 30(4) 490-490, Apr, 2022
【今知っておきたいゲノム医療と遺伝子治療-基礎から臨床まで】遺伝子治療神経筋疾患筋ジストロフィーの遺伝子治療

喜納裕美[早下], 岡田尚巳

小児内科, 54(2) 329-332, Feb, 2022
Improved Transduction of DMD Dog with rAAV-Microdystrophin via Multipotent Mesenchymal Cell Pretreatment

Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 29(4) 287-288, Apr, 2021
Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment

Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Kazuhiro Takao, Tsutomu Igarashi, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 28(4) 327-327, Apr, 2020
【いま、本格化する遺伝子治療遺伝性疾患・がんと戦う新たな一手】(第3章)AAVベクター遺伝子治療静脈注射による方法脊髄性筋萎縮症や筋ジストロフィーに対する遺伝子治療

喜納裕美[早下], 岡田尚巳, 武田伸一

実験医学, 38(2) 225-231, Feb, 2020
生体内における無毒化ヘルペスウイルスベクターの機能性・安全性の検証

宮川世志幸, 丸山基世, 丸山基世, 坂井敦, 佐藤優里子, 黒田誠司, 喜納裕美, 山本基子, 橋詰令太郎, 鈴木秀典 …

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
mdχマウス行動解析による情動障害定量的評価システムの構築

高木篤史, 喜納裕美, 笠原優子, 川上保彦, 伊藤保彦, 岡田尚巳

日本筋学会学術集会プログラム・抄録集, 5回 170-170, Aug, 2019
Systemic Treatment with Dental Pulp-Derived Stem Cells for Muscle Dysfunction in Dystrophic Muscle

Yuko Nitahara Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Yuki Oda, Aki Nakamura Takahashi, Chiaki Masuda, Posadas Herrera Guillermo, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 27(4) 381-381, Apr, 2019
In vivo遺伝子導入に至適化された無毒化ヘルペスウイルスベクターの開発

宮川世志幸, 丸山基世, 丸山基世, 黒田誠治, 坂井敦, 佐藤優里子, 橋詰令太郎, 喜納裕美, 山本基子, JUSTUS Cohen …

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
Systemic rAAV9-Microdystrophin Transduction with MSCs Pre-Treatment Improve Transgene Expression and DMD Phenotype in Canine X-Linked Muscular Dystrophy

Hiromi Hayashita-Kinoh, Yuko N. Kasahara, Mutsuki Kuraoka, Hironori Okada, Kiwamu Imagawa, Tohru Hirato, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 26(5) 123-123, May, 2018
Dental Pulp-Derived Cell Therapy for Duchenne Muscular Dystrophy is Safe and Facilitates Physical Capabilities

Yuko N. Kasahara, Mutsuki Kuraoka, Hiromi Hayashita-Kinoh, Kiwamu Imagawa, Tohru Hirato, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 26(5) 124-124, May, 2018
サルに対するAAVベクター硝子体投与による血中抗体価の検討

五十嵐勉, 高橋和久, 三宅弘一, 小林舞香, 矢口智恵美, 山崎吉之, 喜納裕美, 三宅紀子, 亀谷修平, 島田隆 …

日本眼科学会雑誌, 122(臨増) 260-260, Mar, 2018
特集遺伝子治療における技術革新の現状と課題３.筋ジストロフィーの遺伝子治療

喜納(早下) 裕美, 岡田尚巳

医薬ジャーナル, 54(1) 67-71, Jan 1, 2018
生体内における新規無毒化ヘルペスウイルスベクターの遺伝子発現特性・動態解析

宮川世志幸, 丸山基世, 丸山基世, 黒田誠治, 坂井敦, 佐藤優里子, 喜納裕美, 山本基子, COHEN Justus B, GLORIOSO Joseph C …

日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.3P‐0793 (WEB ONLY), 2018
rAAV-Microdystrophin Transduction with MSCs Pre-Treatment of Canine X-Linked Muscular Dystrophy Improved Transgene Expression and Their DMD Phenotype

Hiromi Hayashita-Kinoh, Yuko N. Kasahara, Mutsuki Kuraoka, Hironori Okada, Kiwamu Imagawa, Tohru Hirato, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 25(5) 99-100, May, 2017
DMDマウス行動解析における情動障害定量的評価システムの構築

高木篤史, 喜納裕美, 笠原優子, 川上康彦, 岡田尚巳, 伊藤保彦

脳と発達, 49(Suppl.) S415-S415, May, 2017
Safe and Effective Cell Therapy Using Dental Pulp Stromal Cells for Duchenne Muscular Dystrophy

Yuko N. Kasahara, Mutsuki Kuraoka, Hiromi Kinoh, Kiwamu Imagawa, Tohru Hirato, Shin'ichi Takeda, Takashi Okada

MOLECULAR THERAPY, 25(5) 195-195, May, 2017
難治性神経・筋疾患の遺伝子治療に向けた新規無毒化ヘルペスウイルスベクターの開発

宮川世志幸, 黒田誠司, 丸山基世, 丸山基世, 喜納裕美, 山本基子, VERLENGIA Gianluca, SIMONATO Michele, COHEN Justus, GLORIOSO Joseph …

日本生化学会大会(Web), 90th, 2017
Transient Ultrasound-Mediated Microbubble-Assisted Modulation of Blood-Brain Interface in Adult Common Marmoset to Improve rAAV-Mediated Brain Transduction

Hironori Okada, Hidetoshi Ishibashi, Chiaki Masuda, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Yuko Nitahara-Kasahara, Yoko Endo-Takahashi, Koichi Kato, Yoichi Negishi, Shin'ichi Takeda …

MOLECULAR THERAPY, 24 S134-S134, May, 2016

Research Projects

経口減感作による組換えAAVの発現効率の改善―筋ジストロフィー治療を目指して

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

石井亜紀子, 喜納裕美
デュシェンヌ型筋ジストロフィーの遺伝子治療を目指した免疫応答回避性薬剤の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

喜納裕美, 喜納宏昭
IMPROVED GENE TRANSDUCTION WITH RECOMBINANT AAV FOLLOWING IMMUNE TOLERANCE.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Ishii Akiko, Okada Takashi, Takeda Sin'ichi, Sankai Tadashi
Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Okada Hironori, OKADA Takashi, TAKEDA Shinichi, KINOH Hiromi, KASAHARA Yuko
Investigation of immune tolerance induction method for gene therapy of muscular dystrophy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Hayashita-Kinoh Hiromi
AAV vector-mediated cell and gene therapy for neuronal diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2015

OKADA Takashi, KINOH Hiromi, OKADA Hironori

Industrial Property Rights

特願2019-014738 核酸送達複合体

岡田尚巳, 喜納裕美, 青木吉嗣, 武田伸一
特開2016-198115 薬剤送達粒子及びその製造方法

岡田尚巳, 武田伸一, 喜納裕美
特許第6007463号薬剤送達粒子及びその製造方法

岡田尚巳, 武田伸一, 喜納裕美
WO2012-144446 薬剤送達粒子及びその製造方法

岡田尚巳, 武田伸一, 喜納裕美

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