島野仁 (Hitoshi Shimano) - 論文

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia.

Yasuhisa Furuta, Yoshinori Osaki, Yoshimi Nakagawa, Song-Iee Han, Masaya Araki, Akito Shikama, Nami Ohuchi, Daichi Yamazaki, Erika Matsuda, Seitaro Nohara …

Journal of atherosclerosis and thrombosis 2024年3月28日

分岐鎖アミノ酸(BCAA)は高齢2型糖尿病患者のQIDSスコアを有意に改善する探索的ランダム化比較試験

松田高明, 鈴木浩明, 菅野洋子, 鈴木康裕, 山中大介, 荒木理沙, 矢作直也, 関谷元博, 川上康, 大崎芳典 …

日本病態栄養学会誌 27(Suppl.) S-96 2024年1月

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.

Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura …

PNAS nexus 2(11) pgad351 2023年11月

Single-cell transcriptome profiling of pancreatic islets from early diabetic mice identifies Anxa10 for Ca2+ allostasis toward β-cell failure.

Kaori Motomura, Takashi Matsuzaka, Shigeyuki Shichino, Tatsuro Ogawa, Hao Pan, Takuya Nakajima, Yasuhito Asano, Toshitsugu Okayama, Tomoyo Takeuchi, Hiroshi Ohno …

Diabetes 2023年10月23日

C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity

Sekiya, Motohiro, Kainoh, Kenta, Saito, Kenji, Yamazaki, Daichi, Tsuyuzaki, Tomomi, Chen, Wanpei, Kobari, Yuto, Nakata, Ayumi, Babe, Haruka, Shimano, Hitoshi

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS Epub 2023年10月

GR-KLF15 pathway controls hepatic lipogenesis during fasting

Takeuchi, Yoshinori, Murayama, Yuki, Aita, Yuichi, Mehrazad Saber, Zahra, Karkoutly, Samia, Tao, Duhan, Katabami, Kyoka, Ye, Chen, Shikama, Akito, Masuda, Yukari …

The FEBS journal 2023年9月

アセトアミノフェン誘導性急性腎障害におけるElovl6の病態生理的意義の解明

杉浦有香, 松井弘樹, 須永浩章, 磯達也, 松坂賢, 島野仁, 倉林正彦, 石井秀樹, 横山知行

The Kitakanto Medical Journal 73(3) 244-244 2023年8月

心臓線維芽細胞における脂肪酸伸長酵素Elovl6が圧負荷に伴う心臓リモデリングに及ぼす役割

横町羽南, 松井弘樹, 須永浩章, 忠木沙耶香, 古川希, 川上亮, 磯達也, 小板橋紀通, 松坂賢, 島野仁 …

The Kitakanto Medical Journal 73(3) 244-245 2023年8月

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.

Motohiro Sekiya, Yang Ma, Kenta Kainoh, Kenji Saito, Daichi Yamazaki, Tomomi Tsuyuzaki, Wanpei Chen, Putu Indah Paramita Adi Putri, Hiroshi Ohno, Takafumi Miyamoto …

Cell reports 112914-112914 2023年8月1日

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

Kenji Saito, Motohiro Sekiya, Kenta Kainoh, Ryunosuke Yoshino, Akio Hayashi, Song-Iee Han, Masaya Araki, Hiroshi Ohno, Yoshinori Takeuchi, Tomomi Tsuyuzaki …

Journal of Biological Chemistry 104890-104890 2023年6月

分岐鎖アミノ酸補充が高齢2型糖尿病患者の骨格筋,耐糖能,腎機能に与える影響探索的ランダム化比較試験

松田高明, 鈴木浩明, 菅野洋子, 鈴木康裕, 山中大介, 荒木理沙, 矢作直也, 関谷元博, 川上康, 大崎芳典 …

糖尿病 66(Suppl.1) S-227 2023年4月

Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia.

Kodama S, Fujihara K, Ishiguro H, Matsubayashi Y, Kitazawa M, Iwanaga M, Yamada T, Kato K, Nakagawa Y, Tanaka S …

J Investig Med 2023年4月査読有り

炭水化物エネルギー比率の算出方法の違いは、糖尿病患者の炭水化物エネルギー比率と心血管疾患発症リスクの関係に影響しうるか

堀川千嘉, 高原充佳, 片上直人, 武田安永, 竹内瑞希, 藤原和哉, 鈴木浩明, 津田謹輔, 吉岡成人, 押田芳治 …

日本栄養・食糧学会大会講演要旨集 77回 314-314 2023年3月

Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis

Yamazaki, Daichi, Osaki, Yoshinori, Suzuki, Hiroaki, Shimano, Hitoshi

BMJ CASE REPORTS 16(3) 2023年3月査読有り責任著者

The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation

Kiyoki, Yusuke, Kato, Takayasu, Kito, Sakura, Matsuzaka, Takashi, Morioka, Shin, Sasaki, Junko, Makishima, Kenichi, Sakamoto, Tatsuhiro, Nishikii, Hidekazu, Obara, Naoshi …

Leukemia 37(4) 910-913 2023年3月

New balance capability index as a screening tool for mild cognitive impairment

Yasuhiro Suzuki, Takumi Tsubaki, Kensuke Nakaya, Genta Kondo, Yoshinori Takeuchi, Yuichi Aita, Yuki Murayama, Akito Shikama, Yukari Masuda, Hiroaki Suzuki …

BMC Geriatrics 23(1) 2023年2月4日

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis

Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han …

BBA Advances 3 100078-100078 2023年

ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice

Yoshida, Kazufumi, Morishima, Yuko, Ano, Satoshi, Sakurai, Hirofumi, Kuramoto, Kenya, Tsunoda, Yoshiya, Yazaki, Kai, Nakajima, Masayuki, Sherpa, Mingma Thering, Matsuyama, Masashi …

The Journal of allergy and clinical immunology 2022年12月30日

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction

Nakajima, Rikako, Sekiya, Motohiro, Furuta, Yasuhisa, Miyamoto, Takafumi, Sato, Masashi, Fukuda, Kuniaki, Hattori, Keiichiro, Suehara, Yasuhito, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru …

Endocrinology, diabetes & metabolism case reports 2022 2022年12月

Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease.

Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka …

American journal of physiology. Gastrointestinal and liver physiology 323(6) G627-G639 2022年12月1日