論文

査読有り
2016年6月

Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice

SCIENTIFIC REPORTS
  • Haruaki Kageyama
  • ,
  • Kanako Shiba
  • ,
  • Satoshi Hirako
  • ,
  • Nobuhiro Wada
  • ,
  • Satoru Yamanaka
  • ,
  • Yukinori Nogi
  • ,
  • Fumiko Takenoya
  • ,
  • Naoko Nonaka
  • ,
  • Tsutomu Hirano
  • ,
  • Shuji Inoue
  • ,
  • Seiji Shioda

6
開始ページ
28200
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep28200
出版者・発行元
NATURE PUBLISHING GROUP

Galanin-like peptide (GALP) has an anti-obesity effect in rats and mice. It has been reported that the uptake of GALP by the brain is higher after intranasal administration than with intravenous injection. This study therefore aimed to clarify the effect of intranasal administration of GALP on the feeding behavior of lean and obese mice. Autoradiography revealed the presence of I-125-GALP in the olfactory bulb and the brain microcirculation. The body weights of ob/ob mice gradually increased during vehicle treatment, but remained unchanged in response to repeated intranasal administration of GALP, with both ob/ob and diet-induced obese mice displaying significantly decreased food intake, water intake and locomotor activity when treated with GALP. These results suggest that intranasal administration is an effective route whereby GALP can exert its effect as an anti-obesity drug.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.1038/srep28200
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27323911
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000378127300001&DestApp=WOS_CPL

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