Papers

Peer-reviewed
Jun, 2016

Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice

SCIENTIFIC REPORTS
  • Haruaki Kageyama
  • Kanako Shiba
  • Satoshi Hirako
  • Nobuhiro Wada
  • Satoru Yamanaka
  • Yukinori Nogi
  • Fumiko Takenoya
  • Naoko Nonaka
  • Tsutomu Hirano
  • Shuji Inoue
  • Seiji Shioda
  • Display all

Volume
6
Number
First page
28200
Last page
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1038/srep28200
Publisher
NATURE PUBLISHING GROUP

Galanin-like peptide (GALP) has an anti-obesity effect in rats and mice. It has been reported that the uptake of GALP by the brain is higher after intranasal administration than with intravenous injection. This study therefore aimed to clarify the effect of intranasal administration of GALP on the feeding behavior of lean and obese mice. Autoradiography revealed the presence of I-125-GALP in the olfactory bulb and the brain microcirculation. The body weights of ob/ob mice gradually increased during vehicle treatment, but remained unchanged in response to repeated intranasal administration of GALP, with both ob/ob and diet-induced obese mice displaying significantly decreased food intake, water intake and locomotor activity when treated with GALP. These results suggest that intranasal administration is an effective route whereby GALP can exert its effect as an anti-obesity drug.

Link information
DOI
https://doi.org/10.1038/srep28200
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27323911
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000378127300001&DestApp=WOS_CPL
ID information
  • DOI : 10.1038/srep28200
  • ISSN : 2045-2322
  • Pubmed ID : 27323911
  • Web of Science ID : WOS:000378127300001

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