EUNYOUNG LEE

Profile Information

Affiliation: assistant professor, Department of Medical Physiology, Chiba University, Graduate School of Medicine

Researcher number: 60583424
J-GLOBAL ID: 202101008545286062
researchmap Member ID: R000025461

Research Interests

Diabetes, obesity, lipid modification, nutrients, organ crosstalk, incretin, adipose tissue, NAFLD

Papers

Mosaic ablation of pancreatic β-cells induces de-differentiation and repetitive proliferation of residual β-cells in adult mice

Ryo Hatano, Xilin Zhang, Eunyoung Lee, Atsushi Kaneda, Tomoaki Tanaka, Takashi Miki

iScience, 110656-110656, Aug, 2024
Hepatic ketone body regulation of renal gluconeogenesis

Ryo Hatano, Eunyoung Lee, Hiromi Sato, Masahiro Kiuchi, Kiyoshi Hirahara, Yoshimi Nakagawa, Hitoshi Shimano, Toshinori Nakayama, Tomoaki Tanaka, Takashi Miki

Molecular Metabolism, 101934-101934, Apr, 2024
Reply to: “Liver-adipose tissue crosstalk in nonalcoholic fatty liver disease: the emerging role of remnant cholesterol” “BAT activation might improve NAFLD in patients, but this might require developing and/or maintaining functionally relevant levels of BAT mass.”

Eunyoung Lee, Hannelie Korf, Antonio Vidal-Puig

Journal of Hepatology, Oct, 2023 InvitedLead author
Identification of genotype-biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency.

Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Masanori Fujimoto, Akitoshi Nakayama, Takahiro Fuchigami, Yuki Taki, Tatsuma Matsuda, Hiroyuki Akamine, Satomi Kono …

Communications biology, 6(1) 787-787, Jul 28, 2023 Peer-reviewed
Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia.

Hanna Deguchi-Horiuchi, Sawako Suzuki, Eun Young Lee, Takashi Miki, Noriko Yamanaka, Ichiro Manabe, Tomoaki Tanaka, Koutaro Yokote

Scientific reports, 13(1) 7291-7291, May 5, 2023 Peer-reviewed
An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease.

Eunyoung Lee, Hannelie Korf, Antonio Vidal-Puig

Journal of hepatology, 78(5) 1048-1062, May, 2023 Peer-reviewedLead author
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Masanori Fujimoto, Masataka Yokoyama, Masahiro Kiuchi, Hiroyuki Hosokawa, Akitoshi Nakayama, Naoko Hashimoto, Ikki Sakuma, Hidekazu Nagano, Kazuyuki Yamagata, Fujimi Kudo …

Nature Communications, 13(1), Sep 15, 2022 Peer-reviewed
Phloretin suppresses carbohydrate-induced GLP-1 secretion via inhibiting short chain fatty acid release from gut microbiome

Yujie Ma, Eunyoung Lee, Hayato Yoshikawa, Tomoe Noda, Junki Miyamoto, Ikuo Kimura, Ryo Hatano, Takashi Miki

Biochemical and Biophysical Research Communications, 621 176-182, Sep, 2022 Peer-reviewedCorresponding author
GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma.

Carol Prives, Sawako Suzuki, Divya Venkatesh, Hiroaki Kanda, Akitoshi Nakayama, Hiroyuki Hosokawa, Eunyoung Lee, Takashi Miki, Brent R Stockwell, Koutaro Yokote …

Cancer research, 82(18) 3209-3222, Jul 27, 2022 Peer-reviewed
Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia

Eunyoung Lee, Xilin Zhang, Tomoe Noda, Junki Miyamoto, Ikuo Kimura, Tomoaki Tanaka, Kenichi Sakurai, Ryo Hatano, Takashi Miki

International Journal of Molecular Sciences, 22(19) 10796-10796, Oct 6, 2021 Peer-reviewedLead author
栄養素(ブドウ糖,アミノ酸,脂質)の代謝と肝疾患と糖尿病 Glutaminolysisの肝臓・膵臓臓器間ネットワークを介した役割解明

鈴木佐和子, 出口ハンナ, 李恩瑛, 三木隆司, 田中知明, 横手幸太郎

糖尿病, 64(Suppl.1) LD-4, May, 2021
GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice

Mitsuo Wada, Kayo Yukawa, Hiroyuki Ogasawara, Koichi Suzawa, Tatsuya Maekawa, Yoshihisa Yamamoto, Takeshi Ohta, Eunyoung Lee, Takashi Miki

iScience, 24(4) 102260-102260, Apr, 2021 Peer-reviewed
Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR‐29 family

Jing Li, Yujing Zhang, Yangyang Ye, Dameng Li, Yuchen Liu, Eunyoung Lee, Mingliang Zhang, Xin Dai, Xiang Zhang, Shibei Wang …

Journal of Extracellular Vesicles, 10(3), Jan, 2021 Peer-reviewed
グルタミン代謝の破綻による糖尿病発症とその分子メカニズム解明

出口ハンナ, 鈴木佐和子, 石渡一樹, 内藤久美子, 山中典子, 真鍋一郎, 李恩瑛, 三木隆司, 龍野一郎, 田中知明 …

肥満研究, 25(Suppl.) 252-252, Oct, 2019
グルタミン代謝遺伝子Glutaminase2が癌と生活習慣病に及ぼす影響

鈴木佐和子, 出口ハンナ, 石渡一樹, 内藤久美子, 藤本真徳, 李恩瑛, 三木隆司, 神田浩明, 龍野一郎, 小出尚史 …

肥満研究, 25(Suppl.) 264-264, Oct, 2019
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

Eunyoung Lee, Emily L. Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig …

International Journal of Molecular Sciences, 20(18) 4448-4448, Sep 10, 2019 Peer-reviewedLead author
Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway

Eun-Young Lee, Xilin Zhang, Junki Miyamoto, Ikuo Kimura, Tomoaki Taknaka, Kenichi Furusawa, Takahito Jomori, Kosuke Fujimoto, Satoshi Uematsu, Takashi Miki

Journal of Endocrinology, 239(3) 267-276, Dec, 2018 Peer-reviewedLead author
Distinct roles of systemic and local actions of insulin on pancreatic β-cells

Takumi Kitamoto, Kenichi Sakurai, Eun Young Lee, Koutaro Yokote, Domenico Accili, Takashi Miki

Metabolism, 82 100-110, May, 2018 Peer-reviewed
Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance

Takashi Miki, Eun Young Lee, Akifumi Eguchi, Kenichi Sakurai, Yuji Sawabe, Tomohiko Yoshida, Keiko Saito, Hidetaka Yokoh, Ko Ishikawa, Koutaro Yokote …

Journal of Diabetes Investigation, 9(3) 512-521, May, 2018 Peer-reviewed
Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia

M Morimoto, E-Y Lee, X Zhang, Y Inaba, H Inoue, M Ogawa, T Shirasawa, O Yokosuka, T Miki

Nutrition & Diabetes, 6(6) e213-e213, Jun, 2016 Peer-reviewedLead author

Misc.

栄養素(ブドウ糖,アミノ酸,脂質)の代謝と肝疾患と糖尿病 Glutaminolysisの肝臓・膵臓臓器間ネットワークを介した役割解明

鈴木佐和子, 出口ハンナ, 李恩瑛, 三木隆司, 田中知明, 横手幸太郎

糖尿病, 64(Suppl.1) LD-4, May, 2021
Mechanism for anti-diabetic action of eicosapentaenoic acid in the high-fat diet-sensitive diabetes mouse model

E. Lee, M. Morimoto, T. Miki

DIABETOLOGIA, 59 S280-S281, Aug, 2016
Fat Transplantation Ameliorates High-Fat Diet-induced Hyperglycemia in InsrP1195L/+ Mice

Eun Young Lee, Kenichi Sakurai, Xilin Zhang, Yasuhiko Minokoshi, Takashi Miki

DIABETES, 64 A480-A480, Jun, 2015
DPP-IV阻害薬による膵β細胞死抑制と増殖促進膵β細胞傷害/再生マウスを用いた検討

森田亜州華, 向英里, 平塚文乃, 高谷具純, 李恩瑛, 三木隆司

糖尿病, 57(Suppl.1) S-143, Apr, 2014
視床下部腹内側核破壊動物の成因と病態

石塚典子, 鈴木洋子, 荒井勝己, 吉村英悟, 影山晴秋, 今関信夫, 林かおり, 高橋美砂子, 佐藤栄子, 石井広二 …

日本体質医学会雑誌, 75(2) 117-124, Jun, 2013
Inhibition of VEGFR signaling suppresses beta-cell injury and diabetes development in SDT rats

Eri Mukai, Takeshi Ohta, Harukiyo Kawamura, Tomohiko Sasase, Eun-Young Lee, Asuka Morita, Nobuya Inagaki, Toshihiko Iwanaga, Takashi Miki

JOURNAL OF PHYSIOLOGICAL SCIENCES, 63 S262-S262, 2013
Distribution of the extracellular calcium-sensing receptors in the cardiovascular regulatory regions in the rat brain

Tomoyuki Kuwaki, Eun-Young Lee, Yasuichiro Fukuda

FASEB JOURNAL, 21(5) A472-A473, Apr, 2007
VMH破壊の膵再生能

仲田瑛子, 坂本雅子, 小川史恵, 李恩瑛, 櫻井純子, 鳥飼陽子, 金井幸子, 影山晴秋, 塩田清二, 井上修二

日本臨床生理学会雑誌, 35(臨増) 67-67, Sep, 2005
VMH破壊ラットにおける膵再生

仲田瑛子, 坂本雅子, 小川史恵, 李恩瑛, 櫻井純子, 鳥飼陽子, 金井幸子, 影山晴秋, 塩田清二, 井上修二

肥満研究, 11(Suppl.) 254-254, Sep, 2005

Research Projects

構造特異的胆汁酸シグナルによる新規脂肪肝抑制機構のマルチオミクス解析

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2026

三木隆司, 波多野亮, 李恩瑛
Roles of KATP channels on the regulation of heat production and metabolism in adipose tissues

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

LEE Eunyoung
Mechanism of proliferation, differentiation, and dedifferentiation of pancreatic beta-cells induced by local signals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

MIKI Takashi
Elucidation of a Novel Fat Depot with Potent Beiging after Cold Exposure

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research), Japan Society for the Promotion of Science, 2018 - 2020

LEE EUNYOUNG
Contribution of adipocytes on regulating bile acid metabolism in liver and glucose homeostasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

LEE Eun Young
Mechanism of repetitive proliferation and plasticity acquisition of pancreatic beta cells: prerequisites for the maintenance of glucose homeostasis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MIKI Takashi
Crosstalk between fat metabolism and insulin signaling in glucose homeostasis: Analysis in fat-sensitive diabetes mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Miki Takashi, MUKAI Eri, LEE Eun Young
Mechanism of high fat diet-induced hyperglycemia in obesity-resistant mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2013

LEE Eun Young

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