2011年3月
AN EFFICIENT SYNTHESIS OF ANTIBIOTIC SF-2312 (3-DIHYDROXYPHOSPHORYL-1,5-DIHYDROXY-2-PYRROLIDONE)
HETEROCYCLES
- ,
- 巻
- 82
- 号
- 2
- 開始ページ
- 1675
- 終了ページ
- +
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3987/COM-10-S(E)80
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
N-Benzyloxy-2-(diethoxyphosphoryl)pent-4-enamide (6) was prepared from ethyl diethoxyphosphorylacetate in a 3-step sequence. Oxidative cleavage of the terminal olefin of 6 with osmium tetroxide and sodium periodate afforded 1-benzyloxy-3-diethoxyphosphoryl-5-hydroxy-2-pyrrolidone (7). The first synthesis of racemic SF-2312 was achieved by treatment of 7 with trimethylsilyl bromide, followed by hydrogenolysis.
- リンク情報
- ID情報
-
- DOI : 10.3987/COM-10-S(E)80
- ISSN : 0385-5414
- Web of Science ID : WOS:000289047600057