2019年6月21日
Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples.
Organic letters
- 巻
- 21
- 号
- 12
- 開始ページ
- 4490
- 終了ページ
- 4494
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.9b01345
While high-colibactin-producing Escherichia coli is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to isolate colibactin adequately. Here, we created fluorescent probes activated by ClbP, the colibactin-maturing peptidase, to identify high-colibactin-producing strains. Our probe served as a valuable clinical diagnostic tool that allowed simple high-throughput diagnostic screening of clinical samples. Furthermore, the probe also allowed identification of high-colibactin producers that would help advance our understanding of colibactin biosynthesis.
- リンク情報
- ID情報
-
- DOI : 10.1021/acs.orglett.9b01345
- ISSN : 1523-7060
- PubMed ID : 31192617