論文

査読有り
2008年

Development of cancer immune therapy by cell targeted nucleic acid delivery

Drug Delivery System
  • Shigeru Kawakami
  • ,
  • Yuriko Higuchi
  • ,
  • Hideyuki Nakanishi
  • ,
  • Yukari Kuramoto
  • ,
  • Yoshiyuki Hattori
  • ,
  • Mitsuru Hashida

23
2
開始ページ
138
終了ページ
144
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2745/dds.23.138

Increased understanding of the molecular pathological mechanisms of tumor, the progress of novel nucleic acids such as CpG oligonucleotides as a strong adjuvant or plasmid DNA(pDNA) encoding tumor-related antigen have provided an encouraging perspective for tumor immunotherapy. Since naked CpG oligonucleotide or pDNA has less therapeutic effect because of their less stability in the body and little accumulation to the immune cells as a target cells, a technology for the in vivo delivery of nucleic acids to immune cells has been necessary. In this review, we will introduce of the tumor immune mechanism and immune cells targeted delivery of nucleic acids for tumor immunotherapy using liposomes. © 2008, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM. All rights reserved.

リンク情報
DOI
https://doi.org/10.2745/dds.23.138
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85024447687&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-1159-3676

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