論文

査読有り 国際誌
2019年10月

Mammalian gene circuits with biomolecule-responsive RNA devices.

Current opinion in chemical biology
  • Hideyuki Nakanishi
  • ,
  • Hirohide Saito

52
開始ページ
16
終了ページ
22
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbpa.2019.04.013

Mammalian synthetic gene circuits are promising tools for both biological studies and therapeutic applications. These circuits enable autonomous cellular state-dependent regulation such as the killing of a target cell population. Biomolecule-responsive RNA devices are preferred components of mammalian synthetic gene circuits, because they enable cell-specific gene regulation with a low risk of insertional mutagenesis. In addition, because the output of one RNA device can be the input of another RNA device, synthetic biologists can construct layered gene circuits for more sophisticated regulation. In this review, we explain recent advancements of biomolecule-responsive mammalian gene circuits based on RNA devices.

リンク情報
DOI
https://doi.org/10.1016/j.cbpa.2019.04.013
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31129468

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