山口秀明 (HIDEAKI YAMAGUCHI) - マイポータル - researchmap

基本情報

所属: 名城大学農学部応用生物化学科

学位: 博士（農学）

J-GLOBAL ID: 202101012839024276
researchmap会員ID: R000023622

研究キーワード

1

ワサビ甘草 6-MITC GA

研究分野

1

ライフサイエンス / 細胞生物学 /

学歴

2

1997年3月

名古屋大学
- 1995年3月

名古屋大学大学院, 農学研究科, 博士後期課程

論文

16

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ.

Beck, K.R., Inderbinen, S.G., Kanagaratnam, S., Kratschmar, D.V., Jetten, A.M., Yamaguchi, H., Odermatt, A.

2019年9月査読有り
Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.

Beck, K.R., Kanagaratnam, S., Kratschmar, D.V., Birk, J., Yamaguchi, H., Sailer, A.W., Seuwen, K., Odermatt, A.

J. Steroid Biochem. Mol. Biol., 190, 19-28 (2019) 2019年6月査読有り
Amino acid sequence of oligopeptide causes marked difference in DNA compaction and transcription.

Zinchenko, A., Hiramatsu, H., Yamaguchi, H., Kubo, K., Murata, S., Kanbe, T., Hazemoto, N., Yoshikawa, K., Akitaya, T.

Biophys. J., 116, 1836-1844 (2019) 2019年5月査読有り
Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fugicides itoraconazole and posaconazole.

Biochem. Pharmacol., 130, 93-103 (2017) 2017年4月
Development of a credible 3D-QSAR CoMSIA model and docking studies for a series of triazoles and tetrazoles containing 11β-HSD1 inhibitors.

SAR QSAR Environ Res., 27, 265-292 (2016) 2016年4月
Structural insight into the homology modeled human N-acetyl-alpha-neuraminidase 3 (NEU3): Part2.

Int. J. Comput. Bioinfo. In Silico Model., 4, 753-760 (2015) 2015年11月
Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells.

Bioorg. & Med. Chem., 22, 440-446 (2014) 2014年1月
Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.

Biochem. Pharmacol., 86, 458-468 (2013) 2013年8月
Homology modeling and structural analysis of human γ-glutamylcysteine ligase catalytic subunit for antitumor drug development.

J. Biophys. Chem. 3, 238-248 2012年8月
Molecular docking and structural analysis of cofactor-protein interactions between NAD+ and 11β-hydroxysteroid dehydrogenase type 2.

J. Mol. Model., 18, 1037-1048 (2012) 2012年3月
Mouse 11β-hydroxysteroid dehydrogenase type 2 for human application: Homology modeling, structural analysis and ligand-receptor interaction.

Cancer Inform. 10 287-295 2011年12月
Ligand-receptor Interaction between Triterpenoids and the 11 beta-Hydroxysteroid dehydrogenase type 2 (11 beta HSD2) Enzyme Predicts Their Toxic Effects against Tumorigenic r/m HM-SFME-1 Cells

Hideaki Yamaguchi, Tao Yu, Toshiro Noshita, Yumi Kidachi, Katsuyoshi Kamiie, Kenji Yoshida, Tatsuo Akitaya, Hironori Umetsu, Kazuo Ryoyama

JOURNAL OF BIOLOGICAL CHEMISTRY 286(42) 36888-36897 2011年10月査読有り
Ligand-receptor interaction between triterpenoids and the 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells.

J. Biol. Chem., 286, 36888-36897 (2011) 286 36888-36897 2011年10月
Selective toxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells is potentially attributed to downregulation of glutathione.

Biochimie 93 1172-1178 2011年7月
Homology modeling and structural analysis of 11β-hydroxysteroid dehydrogenase type 2.

Eur. J. Med. Chem. 46 1325-1330 2011年4月
Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: Induction of actin disruption and tumor cell-selective toxicity.

YAMAGUCHI H

Eur. J. Med. Chem., 45, 2943-2948 (2010) 45 2943-2948 2010年7月