1998年
Inhibition of human telomerase activity by alterperylenol
ONCOLOGY RESEARCH
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- 巻
- 10
- 号
- 9
- 開始ページ
- 449
- 終了ページ
- 453
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- COGNIZANT COMMUNICATION CORP
Human telomerase is a ribonucleoprotein that maintains telomeres by adding TTAGGG tandem repeat sequences using RNA template of the enzyme. Telomerase activity is highly expressed in immortalized cells but not in most somatic cells, except for some renewal tissues, such as hematopoietic stem cells. Therefore, telomerase can be a target for anticancer drugs. Here we show that a fungus metabolite, alterperylenol, inhibits human telomerase activity. Alterperylenol inhibited telomerase activity (IC50 = 30 mu M), but altertoxin I, a structurally related compound, did not affect it at 1 mM. Moreover, alterperylenol did not affect the activity of viral reverse transcriptase at 1 mM.
- リンク情報
- ID情報
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- ISSN : 0965-0407
- Web of Science ID : WOS:000079297400003