2004年12月
Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug
BIOORGANIC & MEDICINAL CHEMISTRY
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- 巻
- 12
- 号
- 24
- 開始ページ
- 6343
- 終了ページ
- 6349
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmc.2004.09.037
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
This paper deals with the synthesis of a stable biotin-phosmidosine conjugate molecule 3 that is required for isolation of biomolecules that bind to phosmidosine (1). It was found that introduction of a biotin residue into the 6-N position of phosmidosine could be carried out by reaction of an N-7-Boc-7,8-dihydro-8-oxoadenosine derivative 13 with phenyl chloroformate followed by displacement with a diamine derivative 6 along with the simultaneous removal of the Boc group and one of the two phenoxycarbonyl groups and the successive condensation with an N-tritylated biotin derivative 5. The condensation of an N-prolylphosphorodiamidite derivative 4 with an appropriately protected 7,8-dihydro-8-oxoadenosine derivative 17 having the biotin residue gave the coupling product 18, which was deprotected to give the biotin-phosmidosine (O-ethyl ester) conjugate 3. (C) 2004 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmc.2004.09.037
- ISSN : 0968-0896
- Web of Science ID : WOS:000225523200002