論文

査読有り 国際誌
2009年11月

The benefits of high-flow management in children with pulmonary atresia.

Artificial organs
  • Yasuhiro Fujii
  • Yasuhiro Kotani
  • Takuya Kawabata
  • Shinya Ugaki
  • Shigeru Sakurai
  • Hironori Ebishima
  • Hideshi Itoh
  • Mahito Nakakura
  • Sadahiko Arai
  • Shingo Kasahara
  • Shunji Sano
  • Tatsuo Iwasaki
  • Yuichiro Toda
  • 全て表示

33
11
開始ページ
888
終了ページ
95
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1525-1594.2009.00895.x
出版者・発行元
WILEY

The high-flow management of cardiopulmonary bypass (CPB; >or=2.4 L/min/m(2)) is a standard strategy used at this institute for children with pulmonary atresia (PA) due to a fear that the blood flow may be diverted by the major/minor aortopulmonary-collateral-arteries and hypervascularization due to long-term hypoxia. The purpose of this study was to describe the validity of high-flow management in children with PA. The CPB records of 23 children with PA who underwent a definitive biventricular repair between Feb 2006 and Nov 2008 were retrospectively reviewed. The mean age at the operation was 33 +/- 22 months. The blood-pressure during bypass was controlled with the same protocol. The mean cooling-temperature was 28.4 +/- 3.7 degrees C. The mean minimum hematocrit was 25.0 +/- 3.4%. The mean maximum bypass flow index at the initiation, the mean maximum flow index during aortic cross-clamping, the mean minimum flow index during aortic cross-clamping, and the mean maximum flow index after rewarming were 3.1 +/- 0.5, 3.1 +/- 0.5, 2.6 +/- 0.4, and 3.2 +/- 0.4 L/min/m(2), respectively. The higher bypass flow indexes significantly correlated with the lower serum lactate levels. The lowest oxygen delivery during CPB had significant influences on the urine output during bypass (R = 0.547, P = 0.007), the serum lactate levels at the end of CPB (R = -0.442, P = 0.035), and the postoperative thoracic effusion (R = -0.459, P = 0.028). A bypass flow index of 2.4 L/min/m(2) may not be sufficient and the maximum requirement of bypass flow index may be 3.2 L/min/m(2) or more in this patient population.

リンク情報
DOI
https://doi.org/10.1111/j.1525-1594.2009.00895.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19817735
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000272127800003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1525-1594.2009.00895.x
  • ISSN : 0160-564X
  • eISSN : 1525-1594
  • PubMed ID : 19817735
  • Web of Science ID : WOS:000272127800003

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