論文

査読有り 筆頭著者 国際誌
2013年6月

Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.

Pathogens and disease
  • Kimito Hirai
  • ,
  • Hiroshi Maeda
  • ,
  • Kazuhiro Omori
  • ,
  • Tadashi Yamamoto
  • ,
  • Susumu Kokeguchi
  • ,
  • Shogo Takashiba

68
1
開始ページ
12
終了ページ
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/2049-632X.12041

Both group I (HSP60) and group II (CCT) chaperonins are targets of autoantibodies. Autoimmune reactions to HSP60 have been well characterized, while immune reactions to group II chaperonin have not been clarified. Methanobrevibacter oralis is a suspected periodontal pathogen with group II chaperonin. In this study, serum responses to M. oralis chaperonin, human HSP60, and CCT subunits were examined using sera from patients with periodontitis and autoimmune diseases. In comparison with healthy controls, periodontitis patients showed significantly higher responses to CCT4 and CCT8 on dot blot analysis. Signals for CCT3 and CCT8 in autoimmune disease patients were significantly higher than in controls. Significant differences were also demonstrated by Western blotting in anti-CCT4 response in both patient groups. All subjects showed strong reactivity to M. oralis chaperonin and faint signals to human HSP60. Autoantibodies were raised against CCT rather than HSP60; and CCT3, CCT4, and CCT8 were shown to be the main targets. Host immune systems may be frequently exposed to chaperonins of Archaea in various habitats. Although further studies of the cross-reactivity between M. oralis chaperonin and human CCT are required, anti-CCT autoantibodies may be involved in the pathogenesis of periodontitis and autoimmune diseases.

リンク情報
DOI
https://doi.org/10.1111/2049-632X.12041
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23620386
ID情報
  • DOI : 10.1111/2049-632X.12041
  • PubMed ID : 23620386

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