MISC

国際誌
2003年

Repair of oxidative cytosine damage by DNA glycosylases

Nucleic Acids Research Supplement
  • Atsushi Katafuchi
  • ,
  • Aya Matsuo
  • ,
  • Hiroaki Terato
  • ,
  • Yoshihiko Ohyama
  • ,
  • Hiroshi Ide

3
開始ページ
269
終了ページ
270
記述言語
英語
掲載種別

5-Hydroxyuracil (HOU) and 5-hydroxycytosine (HOC) are major oxidative lesions of cytosine with mutagenic potentials. Therefore, HOU and HOC need to be removed from DNA to avoid mutation. In this study, oligonucleotide substrates containing HOU and HOC were synthesized by DNA polymerase reactions and tested for DNA glycosylases. Ung exhibited an extremely low activity for HOU as compared to uracil (U). In contrast, hSMUG1 excised HOU and U with a comparable efficiency. Ung and hSMUG1 did not excise HOC.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14510484
ID情報
  • PubMed ID : 14510484

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