Hiroki Akiba

Profile Information

Affiliation: Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
: National Institutes of Biomedical Innovation, Health and Nutrition

ORCID ID: https://orcid.org/0000-0002-1450-5873
J-GLOBAL ID: 201801017050753598
researchmap Member ID: B000298397

External link: http://www.pharm.kyoto-u.ac.jp/kunib/en/biopharm/index.html

Research Areas

Research History

Jan, 2020 - Present

Research Scientist, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition
Jan, 2020 - Present

Assistant Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
Apr, 2022 - Mar, 2023

National Institutes of Biomedical Innovation, Health and Nutrition
Oct, 2016 - Dec, 2019

Project Researcher, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition
Apr, 2016 - Oct, 2016

Project Researcher, School of Engineering, The University of Tokyo
Apr, 2013 - Mar, 2016

Project Researcher, School of Engineering, The University of Tokyo

Education

Apr, 2010 - Mar, 2013

Department of Advanced Interdisciplinary Studies, School of Engineering, The University of Tokyo
Apr, 2008 - Mar, 2010

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
Apr, 2006 - Mar, 2008

Department of Chemistry and Biotechnology, Faculty of Engineering, The University of Tokyo
Apr, 2004 - Mar, 2006

College of Arts and Sciences, The University of Tokyo
Apr, 2001 - Mar, 2004

静岡県立富士高等学校

Committee Memberships

Aug, 2022 - Present

関西支部幹事, 日本化学会生体機能関連化学部会若手の会
Jun, 2018 - Present

将来計画委員会委員, 日本分子イメージング学会

Awards

Sep, 2023

第24回バイオ関連化学シンポジウム講演賞
Jun, 2022

日本蛋白質科学会 2022年度若手奨励賞優秀賞
2019

日本生化学会 JB論文賞
Feb, 2017

Best Poster Award, 11th Annual Symposium on Nanobiotechnology

Papers

Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection

Hiroki Akiba, Junso Fujita, Tomoko Ise, Kentaro Nishiyama, Tomoko Miyata, Takayuki Kato, Keiichi Namba, Hiroaki Ohno, Haruhiko Kamada, Satoshi Nagata …

Communications Biology, 6(1) 987, Sep 27, 2023
A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody–Antigen Interactions with Adjacent Epitopes

Kentaro Nishiyama, Hiroki Akiba, Satoshi Nagata, Kouhei Tsumoto, Haruhiko Kamada, Hiroaki Ohno

Angewandte Chemie International Edition, 62(30), May 31, 2023
Development of a recombinant hepatitis B immunoglobulin derived from B cells collected from healthy individuals administered with hepatitis B virus vaccines: A feasibility study

Rika A. Furuta, Teruhito Yasui, Takeharu Minamitani, Hiroki Akiba, Chizu Toyoda, Ryutaro Tobita, Kazuta Yasui, Ryota Aminaka, Mikako Masaki, Masahiro Satake

Transfusion, 63(6) 1204-1214, Apr 29, 2023
Epitope-dependent thermodynamic signature of single-domain antibodies against hen egg lysozyme

Hiroki Akiba, Hiroko Tamura, Jose M M Caaveiro, Kouhei Tsumoto

The Journal of Biochemistry, 170(5) 623-629, Dec 28, 2021
Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support

Toshihiro Ito, Takeharu Minamitani, Masaki Hayakawa, Ryota Otsubo, Hiroki Akiba, Kouhei Tsumoto, Masanori Matsumoto, Teruhito Yasui

Scientific Reports, 11 22341, Nov 16, 2021
Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto

Scientific Reports, 11(1) 19411-19411, Sep 30, 2021
Novel neutralizing human monoclonal antibodies against tetanus neurotoxin

Takeharu Minamitani, Karin Kiyose, Ryota Otsubo, Toshihiro Ito, Hiroki Akiba, Rika A. Furuta, Tsuyoshi Inoue, Kouhei Tsumoto, Masahiro Satake, Teruhito Yasui

Scientific Reports, 11(1), Jun 9, 2021
The Kg‐antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn

Mitsunobu Tanaka, Takaaki Abe, Takeharu Minamitani, Hiroki Akiba, Toshihiro Horikawa, Ryutaro Tobita, Kazumi Isa, Kenichi Ogasawara, Hideo Takahashi, Hidemi Tateyama …

British Journal of Haematology, 191(5) 920-926, Jul 23, 2020 Peer-reviewed
Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A. Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh …

ACS Nano, 14(6) 6729-6742, Jun 23, 2020 Peer-reviewed
64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time

Kentaro Fujiwara, Hiroki Akiba, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kotaro Nagatsu, Ming-Rong Zhang, Hiroko Iwanari, Osamu Kusano-Arai, Shota Kudo …

Nuclear Medicine Communications, 41(7) 688-695, May 1, 2020 Peer-reviewed
GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab.

Daiki Kato, Tomonori Yaguchi, Takashi Iwata, Yuki Katoh, Kenji Morii, Kinya Tsubota, Yoshiaki Takise, Masaki Tamiya, Haruhiko Kamada, Hiroki Akiba …

eLife, 9 e49392, Mar 31, 2020 Peer-reviewed
Computer-guided library generation applied to the optimization of single-domain antibodies

Akiba H, Tamura H, Caaveiro JMM, Tsumoto K

Prot. Eng. Des. Selec., 32(9) 423-431, Mar, 2020 Peer-reviewed
Generation of biparatopic antibody through two step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher

Akiba H, Takayanagi K, Kusano-Arai O, Iwanari H, Hamakubo T, Tsumoto K

Biotechnology Reports, 25 e00418, Mar, 2020 Peer-reviewed
Variantome driven antibody/peptide design via artificial intelligence and distributed cooperative automatic experiment devices

35(1) 61-63, Jan, 2020 Invited
Development and activities, including immunocomplex formation, of biparatopic antibodies and alternative scaffold proteins

Hiroki Akiba

Translational and Regulatory Sciences, 2(1) 1-6, Jan, 2020 Peer-reviewedInvited
Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody.

Akiba H, Tamura H, Kiyoshi M, Yanaka S, Sugase K, Caaveiro JMM, Tsumoto K

Scientific reports, 9(1) 15481-15481, Oct, 2019 Peer-reviewed
¹¹¹In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging probe for diagnosing gastric cancer and lymph-node metastasis.

Fujiwara K, Tsuji AB, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T …

Annals of nuclear medicine, 34(1) 13-23, Oct, 2019 Peer-reviewed
Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design

Akiba H, Satoh R, Nagata S, Tsumoto K

Antibody Therapeutics, 2(2) 65-69, Sep, 2019 Peer-reviewed
新規ラベル化プロテオミクス技術による創薬ターゲット探索技術の開発

鎌田春彦, 中山泰亮, 秋葉宏樹, 津本浩平, 西村翔太, 井上豪

電気泳動, 63(Suppl.) 188-188, Jul, 2019
Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody.

Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K

Journal of structural biology, 204(2) 207-214, Aug, 2018 Peer-reviewed

Misc.

がん転移に関するLI-cadherin一塩基多型の分子メカニズム

由井杏奈, 菊池智佳, 郷田秀一郎, 工藤翔太, 秋葉宏樹, 中木戸誠, 黒田大祐, 黒田大祐, 長門石曉, 長門石曉 …

日本生化学会大会(Web), 92nd, 2019
LI-cadherinの一変異が大腸がんのリンパ節転移に与える影響

由井杏奈, 菊池智佳, 工藤翔太, 秋葉宏樹, 中木戸誠, 長門石曉, 長門石曉, 新井修, 岩成宏子, 浜窪隆雄 …

日本がん転移学会学術集会・総会プログラム抄録集, 27th, 2018
Imaging of CDH17-positive gastric cancer xenografts with 64Cu-labeled anti-CDH17 IgG PET

K. Fujiwara, K. Koyama, K. Suga, M. Takahashi, O. Kusano-Arai, K. Mitsui, H. Akiba, H. Iwanari, K. Tsumoto, T. Hamakubo …

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42 S420-S420, Oct, 2015

Presentations

抗体エピトープの特徴付けとバイパラトピック抗体への展開

秋葉宏樹

バイオインタラクション研究会第 11 回ワークショップ, Nov 24, 2020 Invited

Research Projects

化学的連結法による低分子化抗体ターゲティングシステムの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

秋葉宏樹
バイパラトピック抗体のパネル化による機能的人工抗体の探索デザインの高度化

創薬基盤推進研究事業, 日本医療研究開発機構, May, 2018 - Mar, 2023
タンパク質リン酸化を選択的に認識する化学プローブの創製

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2011 - 2012

秋葉宏樹

Industrial Property Rights

特許7101433 エピトープ領域架橋型バイパラトピック抗体、及びそれを製造する方法

秋葉宏樹, 津本浩平, 永田諭志

Profile Information

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Presentations

Research Projects

Industrial Property Rights

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