論文

査読有り
2016年11月

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity

JOURNAL OF NEUROSCIENCE
  • Barbara A. Sorg
  • ,
  • Sabina Berretta
  • ,
  • Jordan M. Blacktop
  • ,
  • James W. Fawcett
  • ,
  • Hiroshi Kitagawa
  • ,
  • Jessica C. F. Kwok
  • ,
  • Marta Miquel

36
45
開始ページ
11459
終了ページ
11468
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.2351-16.2016
出版者・発行元
SOC NEUROSCIENCE

Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and after exposure to drugs of abuse. Here the focus is on how a major component of PNNs, chondroitin sulfate proteoglycans, control plasticity, and on the role of PNNs in memory in normal aging, in a tauopathy model of Alzheimer's disease, and in drug addiction. Also discussed is how altered extracellular matrix/PNN formation during development may produce synaptic pathology associated with schizophrenia, bipolar disorder, major depression, and autism spectrum disorders. Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases.

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.2351-16.2016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27911749
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000391054300011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.2351-16.2016
  • ISSN : 0270-6474
  • PubMed ID : 27911749
  • Web of Science ID : WOS:000391054300011

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