論文

査読有り
2006年12月

Persorption of luminal antigenic molecule and its specific antibody via apoptotic epithelial cells of intestinal villi and Peyer's patches into peripheral blood in rats

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Midori Yuji
  • ,
  • Masahito Tsubata
  • ,
  • Keigi Chin
  • ,
  • Sachiko Onishi
  • ,
  • Tetsurou Inamoto
  • ,
  • Wang-Mei Qi
  • ,
  • Katsuhiko Warita
  • ,
  • Toshifumi Yokoyama
  • ,
  • Nobuhiko Hoshi
  • ,
  • Hiroshi Kitagawa

68
12
開始ページ
1297
終了ページ
1305
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.68.1297
出版者・発行元
JAPAN SOC VET SCI

The possibility of persorption of bovine serum albumin (BSA) molecules from mucous epithelial cells and its mechanism were investigated in rats orally pre-immunized by BSA for 14 consecutive days. In the small and large intestines, both the BSA antigen (BSA-Ag) and its specific antibody (SpAb) were absorbed by the epithelial cells at the late apoptotic stage (ApoEp), and were subsequently transcytosed by membranes of the small vesicles. The basal cytoplasms containing highly-concentrated BSA-Ag and SpAb were occasionally fragmented into small cytoplasmic droplets that were secreted into the lamina propria. In Peyer's patches, both BSA-Ag and SpAb were more actively absorbed and transcytosed toward the dome area by the ApoEp of the dome apex than by the M cells. BSA-Ag and SpAb were finally persorbed into the portal blood and lymph, but were never secreted into the bile. They were also engulfed by macrophage-like cells in the villous lamina propria, mesenteric lymph node and spleen, and by hepatocytes in the liver. These findings suggest that sensitized soluble luminal antigens are taken up by ApoEp in the small intestine and are finally persorbed into the peripheral blood. The uptake of luminal antigen might be mediated by its luminal SpAb.

リンク情報
DOI
https://doi.org/10.1292/jvms.68.1297
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17213698
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000243327100007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1292/jvms.68.1297
  • ISSN : 0916-7250
  • PubMed ID : 17213698
  • Web of Science ID : WOS:000243327100007

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