論文

査読有り
2003年10月

Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate

CURRENT OPINION IN STRUCTURAL BIOLOGY
  • K Sugahara
  • ,
  • T Mikami
  • ,
  • T Uyama
  • ,
  • S Mizuguchi
  • ,
  • K Nomura
  • ,
  • H Kitagawa

13
5
開始ページ
612
終了ページ
620
記述言語
英語
掲載種別
DOI
10.1016/j.sbi.2003.09.011
出版者・発行元
CURRENT BIOLOGY LTD

Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces. They have been implicated in the signaling functions of various heparin-binding growth factors and chemokines, and play critical roles in the development of the central nervous system. They also function as receptors for various pathogens. These functions are closely associated with the sulfation patterns of the glycosaminoglycan chains. Surprisingly, nonsulfated chondroitin is indispensable in the morphogenesis and cell division of Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned chondroitin synthase gene and by the analysis of mutants of squashed vulva genes.

リンク情報
DOI
https://doi.org/10.1016/j.sbi.2003.09.011
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/14568617
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000186317900012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.sbi.2003.09.011
  • ISSN : 0959-440X
  • PubMed ID : 14568617
  • Web of Science ID : WOS:000186317900012

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