2003年1月
Appearance of T cell Subpopulations in the chicken and embryo retina
JOURNAL OF VETERINARY MEDICAL SCIENCE
- ,
- ,
- 巻
- 65
- 号
- 1
- 開始ページ
- 23
- 終了ページ
- 28
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.65.23
- 出版者・発行元
- JAPAN SOC VET SCI
Under pathological conditions such as autoimmune encephalomyelitis or autoimmune uveoretinitis, many T cells infiltrate the central nervous system (CNS) and retina. Even in normal condition, a small number of T cells are detected in the CNS. However the characteristics of the T cells are not defined. To investigate the T cell characteristics in a healthy retina, the chicken and the embryo were observed by morphological and immunohistochemical methods. In the chicken retina, T cells were regularly detected, and the main subset was CD-8(+)/gammadelta cells. Developmentally, CD positive cells appeared on embryonic day 13, and the constituent T cell repertoires became the same as in the chicken by embryonic day 17. Many T cell repertoires were detected on embryonic day 15 and 16. The present results confirm that the retina receives an immunological surveillance by T cells. The composition of T cells in retina is constructed after embryonic day 17. Many ganglion cells die in embryonic days 15 and 16. So the T cell subsets in these periods may involve in autoimmune diseases.
- リンク情報
- ID情報
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- DOI : 10.1292/jvms.65.23
- ISSN : 0916-7250
- eISSN : 1347-7439
- PubMed ID : 12576700
- Web of Science ID : WOS:000180715100004