Hiroshi Ochiai

J-GLOBAL         Last updated: Sep 12, 2019 at 16:56
 
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Name
Hiroshi Ochiai
E-mail
ochiaihiroshima-u.ac.jp
URL
https://www.researchgate.net/profile/Hiroshi_Ochiai3/
Affiliation
Hiroshima University
Job title
PRESTO researcher
Degree
Ph.D. in Sci.(Hiroshima University)
Other affiliation
Hiroshima University/Graduate school of Science/ Department of Mathematical and Life Sciences
Research funding number
60640753
ORCID ID
0000-0002-2200-1325

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
 - 
Today
Lecturer, Graduate School of Integrated Sciences for Life, Hiroshima University
 
Dec 2015
 - 
Mar 2019
Lecturer (Special Appointment), Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University
 
Oct 2015
 - 
Mar 2019
PRESTO researcher, Japan Science and Technology Agency (JST)
 
Jun 2012
 - 
Mar 2013
Assistant Professor, Department of Genetics and Cell Biology, Hiroshima University・Research Institute for Radiation Biology and Medicine
 
Apr 2013
 - 
Sep 2015
Lecturer (Special Appointment), Research Center for the Mathematics on Chromatin Live Dynamics, Hiroshima University
 

Education

 
Apr 2008
 - 
Mar 2011
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University
 

Committee Memberships

 
Jul 2015
 - 
Today
Scientific Reports  Editorial Board Member
 

Awards & Honors

 
Nov 2016
Hiroshima University President Award, Hiroshima University
 
Jun 2008
Hiroshima University Excellent Student Scholarship, Hiroshima University
 
Mar 2007
Faculty of Science Commendation, Hiroshima University
 

Published Papers

 
Sungrim Seirin-Lee, Fumitaka Osakada, Junichi Takeda, Satoshi Tashiro, Ryo Kobayashi, Takashi Yamamoto, Hiroshi Ochiai
PLoS Computational Biology   15(9) e1007289   Sep 2019   [Refereed]
Jieru Li, Ankun Dong, Kamola Saydaminova, Hill Chang, Guanshi Wang, Hiroshi Ochiai, Takashi Yamamoto, Alexandros Pertsinidis
Cell   178(2) 491-506   May 2019   [Refereed]
Hiroshi Ochiai
676    Feb 2019   [Invited]
Matsushita M, Ochiai H, Suzuki KT, Hayashi S, Yamamoto T, Awazu A, Sakamoto N.
Journal of Cell Science   130(24) 4097-4107   Nov 2017   [Refereed]
Satoru Ishihara, Naoe Kotomura, Naoki Yamamoto, Hiroshi Ochiai
Analytical Biochemistry   531(15) 37-44   May 2017   [Refereed]
Matsuura S., Royba E., Akutsu SN., Yanagihara H., Ochiai H., Kudo Y., Tashiro S., Miyamoto T.
ANNALS OF THE ICRP   45(1 Suppl) 290-296   Mar 2016   [Invited]
Hiroshi Ochiai
International Journal of Molecular Sciences   16(9) 21128-21137   Sep 2015   [Refereed][Invited]
Hiroshi Ochiai, Takeshi Sugawara, Takashi Yamamoto
Nucleic Acids Research   43(19) e127   Jun 2015   [Refereed]
Tatsuo Miyamoto, Kosuke Hosoba, Hiroshi Ochiai, Ekaterina Royba, Hideki Izumi, Tetsushi Sakuma, Takashi Yamamoto, Brian~David Dynlacht, Shinya Matsuura
Cell Reports   10(5) 664   Feb 2015   [Refereed]
Hiroshi Ochiai, Takeshi Sugawara, Tetsushi Sakuma, Takashi Yamamoto
Scientific Reports   4 7125   Nov 2014   [Refereed]
H. Ochiai, T. Miyamoto, A. Kanai, K. Hosoba, T. Sakuma, Y. Kudo, K. Asami, A. Ogawa, A. Watanabe, T. Kajii, T. Yamamoto, S. Matsuura
Proceedings of the National Academy of Sciences   111(4) 1461-1466   Jan 2014   [Refereed]
Tetsushi Sakuma, Hiroshi Ochiai, Takehito Kaneko, Tomoji Mashimo, Daisuke Tokumasu, Yuto Sakane, Ken-ichi Suzuki, Tatsuo Miyamoto, Naoaki Sakamoto, Shinya Matsuura, Takashi Yamamot
Scientific Reports   3    Nov 2013   [Refereed]
K.-i. T. Suzuki, Y. Isoyama, K. Kashiwagi, T. Sakuma, H. Ochiai, N. Sakamoto, N. Furuno, A. Kashiwagi, T. Yamamoto
Biology Open   2(5) 448-452   May 2013   [Refereed]
Tetsushi Sakuma, Sayaka Hosoi, Knut Woltjen, Ken-ichi Suzuki, Keiko Kashiwagi, Housei Wada, Hiroshi Ochiai, Tatsuo Miyamoto, Narudo Kawai, Yasunori Sasakura, Shinya Matsuura, Yasushi Okada, Atsuo Kawahara, Shigeo Hayashi, Takashi Yamamoto
Genes to Cells   18(4) 315-326   Apr 2013   [Refereed]
Hiroshi Ochiai, Tetsushi Sakuma, Shinya Matsuura, Takashi Yamamoto
31(1) 95-100   Jan 2013   [Invited]
Takahito Watanabe, Hiroshi Ochiai, Tetsushi Sakuma, Hadley W. Horch, Naoya Hamaguchi, Taro Nakamura, Tetsuya Bando, Hideyo Ohuchi, Takashi Yamamoto, Sumihare Noji, Taro Mito
Nature Communications   3 1017   Aug 2012   [Refereed]
Xiaohong Song, Yuya Sato, Athary Felemban, Ayako Ito, Mahmud Hossain, Hiroshi Ochiai, Takashi Yamamoto, Kiyotoshi Sekiguchi, Hideaki Tanaka, Kunimasa Ohta
Developmental Biology   368(1) 109-117   Aug 2012   [Refereed]
H. Ochiai, N. Sakamoto, K. Fujita, M. Nishikawa, K.-i. Suzuki, S. Matsuura, T. Miyamoto, T. Sakuma, T. Shibata, T. Yamamoto
Proceedings of the National Academy of Sciences   109(27) 10915-10920   Jul 2012   [Refereed]
Satoshi Ansai, Hiroshi Ochiai, Yuta Kanie, Yasuhiro Kamei, Yuki Gou, Takeshi Kitano, Takashi Yamamoto, Masato Kinoshita
Development, Growth & Differentiation   54(5) 546-556   Jun 2012   [Refereed]
Narudo Kawai, Hiroshi Ochiai ,Tetsushi Sakuma, Lixy Yamada, Hitoshi Sawada, Takashi Yamamoto, Yasunori Sasakura
Development, Growth & Differentiation   54(5) 535-545   May 2012   [Refereed]
Sakuma T, Ohnishi K, Fujita K, Ochiai H, Sakamoto N, Yamamoto T.
Development Genes and Evolution   221(3) 157-166   Jun 2011   [Refereed]
Ochiai H, Fujita K, Suzuki K, Nishikawa M, Shibata T, Sakamoto N, Yamamoto T.
Genes to Cells   15(8) 875-885   Aug 2010   [Refereed]
Okamitsu Y, Yamamoto T, Fujii T, Ochiai H, Sakamoto N.
ZOOLOGICAL SCIENCE   27(6) 477-486   Jun 2010   [Refereed]
Fujii T, Sakamoto N, Ochiai H, Fujita K, Okamitsu Y, Sumiyoshi N, Minokawa T, Yamamoto T.
Developmental Dynamics   238(10) 2511-2521   Oct 2009   [Refereed]
Karasawa K, Sakamoto N, Fujita K, Ochiai H, Fujii T, Akasaka K, Yamamoto T.
ZOOLOGICAL SCIENCE   26(10) 686-690   Oct 2009   [Refereed]
Ochiai H, Sakamoto N, Suzuki K, Akasaka K, Yamamoto T.
Developmental Dynamics   237(9) 2475-2482   Sep 2008   [Refereed]
Ochiai H, Sakamoto N, Momiyama A, Akasaka K, Yamamoto T.
Mechanisms of Development   125(1-2) 2-17   Feb 2008   [Refereed]

Books etc

 
Imaging Gene Expression, Shav-Tal Y. (eds)
Hiroshi Ochiai (Part:Contributor, Real-Time Observation of Localization and Expression (ROLEX) System for Live Imaging of the Transcriptional Activity and Nuclear Position of a Specific Endogenous Gene)
Humana   Aug 2019   ISBN:978-1-4939-9674-2
医療応用をめざすゲノム編集 最新動向から技術・倫理的課題まで 真下 知士/金田 安史 編
Hiroshi Ochiai (Part:Contributor)
KAGAKUDOJIN   Jun 2018   
Genome Editing in Animals
Hiroshi Ochiai, Takashi Yamamoto (Part:Contributor, Construction and Evaluation of Zinc Finger Nucleases)
Springer New York   Jun 2017   ISBN:978-1-4939-7128-2
Targeted Genome Editing Using Site-specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System
Hiroshi Ochiai, Takashi Yamamoto (Part:Contributor, Genome editing using zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs))
Springer   Dec 2014   ISBN:978-4-431-55227-7

Conference Activities & Talks

 
CRISPR library screening enables identification of transcriptional bursting related genes
Hiroshi Ochiai, Takashi Yamamoto
4th Annual Meeting of The Japanease Society for Genome Editing   5 Jun 2019   
Role of dynamic nuclear deformation on genomic architecture reorganization [Invited]
Hiroshi Ochiai, S. Seirin-Lee, Fumitaka Osakada, Junichi Takeda
The 41th Annual Meeting of the Molecular Biology Society of Japan   30 Nov 2018   
Development of comprehensive analysis technology for intercellular phenotypic heterogeneity [Invited]
Hiroshi Ochiai
The 41th Annual Meeting of the Molecular Biology Society of Japan   28 Nov 2018   
Comprehensive analysis of regulatory mechanisms of gene expression noise in mouse embryonic stem cells [Invited]
Hiroshi Ochiai
The 91st Annual Meeting of the Japanese Biochemical Society   26 Sep 2018   
Understanding Higher-order genomic structure using genome editing technology [Invited]
Hiroshi Ochiai
JAAM2018   25 May 2018   
Comprehensive analysis of regulatory mechanisms of intrinsic gene expression noise in mouse embryonic stem cells [Invited]
Hiroshi Ochiai, Mana Umeda, Tetsutaro Hayashi, Mika Yoshimura, Akihito Harada, Yasuyuki Ohkawa, Takashi Yamamoto, Itoshi Nikaido
The 12th Annual Meeting of the Japanese Society for Epigenetics   24 May 2018   
Relationship between kinetics of higher genome structure and transcription activity [Invited]
Hiroshi Ochiai
ConBio2017   7 Dec 2017   
Relationship between kinetics of higher-order genomic structure and transcriptional activity [Invited]
Hiroshi Ochiai
The 55th Annual Meeting of the Biophysical Society of Japan   21 Sep 2017   
Dynamic nuclear deformation induces nuclear architecture remodeling [Invited]
Hiroshi Ochiai, Seirin S. Lee
The 39th Annual Meeting of the Molecular Biology Society of Japan   30 Nov 2016   
Single Base Pair Genome-Editing Technology and Its Future Applications [Invited]
Hiroshi Ochiai
13th Japanese-German Frontiers of Science Symposium   7 Oct 2016   
A challenging interdisciplinary approach to elucidate a mystery of remodeling process in nuclear architecture (Part II: Experiment) [Invited]
Hiroshi Ochiai
JSMB2016   9 Sep 2016   
Relationship between nuclear dynamics and gene expression noise in pluripotent stem cell [Invited]
Hiroshi Ochiai
The 68th Annual Meeting of the Japan Society for Cell Biology   16 Jun 2016   
Active nuclear dynamics promotes heterochromatin clustering
Hiroshi Ochiai
The 4th International Symposium of the Mathematics on Chromatin Live Dynamics   9 Dec 2015   
Simultaneous live imaging of a specific gene's transcription and dynamics. [Invited]
Ochiai H., Sugawara T. & Yamamoto T.
BMB2015   3 Dec 2015   
Simultaneous live imaging of the transcription and nuclear position of specific genes [Invited]
Hiroshi Ochiai
2015 TIC (Transcription Imaging Consortium) meeting, Janelia Research Campus (VA), USA   10 Sep 2015   TIC
Simultaneous Live Imaging of the Transcription and Nuclear Position of Specific Genes
Hiroshi Ochiai
International Symposium on Chromatin Structure, Dynamics, and Function, Awaji, Japan   23 Aug 2015   
Simultaneous live-imaging of gene position and its transcriptional activity in mouse embryonic stem cells
Hiroshi Ochiai, Takeshi Sugawara, Takashi Yamamoto
4D nucleome, Hiroshima   18 Dec 2014   
Stochastic promoter activation affects gene expression variability in murine embryonic stem cells
Hiroshi Ochiai, Takeshi Sugawara, Tetsushi Sakuma, Takashi Yamamoto
CSHL meeting, NUCLEAR ORGANIZATION & FUNCTION, CSHL, NY   19 Aug 2014   Cold Spring Harbor Laboratory Meeting & Courses
TALEN-mediated single-base-pair editing in PCS syndrome [Invited]
Hiroshi Ochiai
3rd International Genome Engineering & Genome Editing-2014 Meeting on 'Synthetic Biology to Zinc Finger Nucleases & CRISPRs Regulation', Waltham, MA(USA)   5 May 2014   
TALEN-mediated single-base-pair editing reveals the functional significance of an intergenic single nucleotide variant [Invited]
Hiroshi Ochiai
International Symposium on RNAi and Genome Editing Research, Tokushima University   14 Mar 2014   

Research Grants & Projects

 
JSPS: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Project Year: Jul 2018 - Mar 2023    Investigator(s): Noriko Saitoh
Japan Science and Technology Agency: PRESTO
Project Year: Oct 2015 - Mar 2019    Investigator(s): Hiroshi Ochiai
Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells
Project Year: 2015 - 2015    Investigator(s): Hiroshi Ochiai

Social Contribution

 
Organizaing workshop "Understanding of nuclear function by imaging and quantitative analysis of chromatin dynamics"
[Planner]  Hiroshi Ochiai, Masaru Ueno  ConBio2017  (Kobe Portopia Hotel)  6 Dec 2017 - 9 Dec 2017
Organizing the symposium "Understanding genomic functions in multiscale from chromatin structure to intranuclear dynamics"
[Planner]  Kayo Hibino, Hiroshi Ochiai  The 55th Annual Meeting of the Biophysical Society of Japan  21 Sep 2017
Organizing the symposium "Understanding of nuclear function by live imaging of chromatin dynamics"
[Planner]  Masaru Ueno, Hiroshi Ochiai  The 39th Annual Meeting of the Molecular Biology Society of Japan  30 Nov 2016