論文

国際誌
2020年10月16日

Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.

Communications biology
  • Shinichiro Atsumi
  • ,
  • Hiroto Katoh
  • ,
  • Daisuke Komura
  • ,
  • Itaru Hashimoto
  • ,
  • Genta Furuya
  • ,
  • Hirotomo Koda
  • ,
  • Hiroki Konishi
  • ,
  • Ryohei Suzuki
  • ,
  • Asami Yamamoto
  • ,
  • Satsuki Yuba
  • ,
  • Hiroyuki Abe
  • ,
  • Yasushi Rino
  • ,
  • Takashi Oshima
  • ,
  • Tetsuo Ushiku
  • ,
  • Masashi Fukayama
  • ,
  • Yasuyuki Seto
  • ,
  • Shumpei Ishikawa

3
1
開始ページ
588
終了ページ
588
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-020-01305-5

Despite the accumulating evidences of the significance of humoral cancer immunity, its molecular mechanisms have largely remained elusive. Here we show that B-cell repertoire sequencing of 102 clinical gastric cancers and molecular biological analyses unexpectedly reveal that the major humoral cancer antigens are not case-specific neo-antigens but are rather commonly identified as ribonucleoproteins (RNPs) in the focal adhesion complex. These common antigens are shared as autoantigens with multiple autoimmune diseases, suggesting a direct molecular link between cancer- and auto-immunity on the focal adhesion RNP complex. This complex is partially exposed to the outside of cancer cell surfaces, which directly evokes humoral immunity and enables functional bindings of antibodies to cancer cell surfaces in physiological conditions. These findings shed light on humoral cancer immunity in that it commonly targets cellular components fundamental for cytoskeletal integrity and cell movement, pointing to a novel modality of immunotherapy using humoral immunological reactions to cancers.

リンク情報
DOI
https://doi.org/10.1038/s42003-020-01305-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33067514
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567837

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