MISC

2017年

Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3C–H bonds

Chemical and Pharmaceutical Bulletin
  • Kazuhiro Morisaki
  • ,
  • Kazuhiro Morisaki
  • ,
  • Yuta Kondo
  • ,
  • Masanao Sawa
  • ,
  • Hiroyuki Morimoto
  • ,
  • Takashi Ohshima

65
11
開始ページ
1089
終了ページ
1092
DOI
10.1248/cpb.c17-00580

© 2017 The Pharmaceutical Society of Japan. This note describes the construction of tetrasubstituted carbon stereocenters via palladium-catalyzed allylation of sp3C–H bonds of 2,2,2-trifluoroethylamine derivatives. The presence of 2-pyridyl group of the imines derived from 1-substituted-2,2,2-trifluoroethylamine was key to promoting the reaction efficiently, allowing an access to a variety of 1-allylated 2,2,2-trifluoroethylamine derivatives with tetrasubstituted carbon stereocenters.

リンク情報
DOI
https://doi.org/10.1248/cpb.c17-00580
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29093297
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85033721759&partnerID=MN8TOARS
ID情報
  • DOI : 10.1248/cpb.c17-00580
  • ISSN : 0009-2363
  • ORCIDのPut Code : 54231875
  • PubMed ID : 29093297
  • SCOPUS ID : 85033721759

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