2005
Non-C<inf>2</inf>-symmetric, chirally economical, and readily tunable linked-binols: Design and application in a direct catalytic asymmetric mannich-type reaction
Angewandte Chemie - International Edition
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- Volume
- 44
- Number
- 22
- First page
- 3470
- Last page
- 3474
- Language
- English
- Publishing type
- DOI
- 10.1002/anie.200500425
- Publisher
- WILEY-V C H VERLAG GMBH
(Chemical Equation Presented) An achiral unit is shown to be better than a chiral unit in promoting an asymmetric reaction. Non-C2-symmetric linked-binols 1 with one chiral 1,1′-bi-2-naphthol unit and one flexible achiral unit are employed as ligands in direct catalytic asymmetric Mannich-type reactions (see scheme; TON = turnover number). With as little as 0.01 mol% of ligand 1 a and 0.04 mol% of Et2Zn, the reaction proceeded smoothly to give the product in 98% ee. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
- Link information
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- DOI
- https://doi.org/10.1002/anie.200500425
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15861441
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229549100024&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-20444420552&partnerID=MN8TOARS
- ID information
-
- DOI : 10.1002/anie.200500425
- ISSN : 1433-7851
- ORCID - Put Code : 34143204
- Pubmed ID : 15861441
- SCOPUS ID : 20444420552
- Web of Science ID : WOS:000229549100024