論文

査読有り
2017年

Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

ACS Catalysis
  • Deguchi, T.
  • ,
  • Xin, H.-L.
  • ,
  • Morimoto, H.
  • ,
  • Ohshima, T.

7
5
開始ページ
3157
終了ページ
3161
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acscatal.7b00442
出版者・発行元
AMER CHEMICAL SOC

Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.

Web of Science ® 被引用回数 : 67

リンク情報
DOI
https://doi.org/10.1021/acscatal.7b00442
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401054300009&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85020175817&partnerID=MN8TOARS
ID情報
  • DOI : 10.1021/acscatal.7b00442
  • ISSN : 2155-5435
  • ORCIDのPut Code : 34143217
  • SCOPUS ID : 85020175817
  • Web of Science ID : WOS:000401054300009

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