2017年
Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides
ACS Catalysis
- ,
- ,
- ,
- 巻
- 7
- 号
- 5
- 開始ページ
- 3157
- 終了ページ
- 3161
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acscatal.7b00442
- 出版者・発行元
- AMER CHEMICAL SOC
Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.
- リンク情報
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- DOI
- https://doi.org/10.1021/acscatal.7b00442
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000401054300009&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85020175817&partnerID=MN8TOARS
- ID情報
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- DOI : 10.1021/acscatal.7b00442
- ISSN : 2155-5435
- ORCIDのPut Code : 34143217
- SCOPUS ID : 85020175817
- Web of Science ID : WOS:000401054300009