2020年1月3日
Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines
Organic Letters
- 巻
- 22
- 号
- 1
- 開始ページ
- 120
- 終了ページ
- 125
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.9b04038
Copyright © 2019 American Chemical Society. N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using commercially available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described.
- リンク情報
- ID情報
-
- DOI : 10.1021/acs.orglett.9b04038
- ISSN : 1523-7052
- eISSN : 1523-7052
- ORCIDのPut Code : 76291487
- PubMed ID : 31854997
- SCOPUS ID : 85077475961