久保田浩行 (Kubota Hiroyuki) - マイポータル

基本情報

所属: 九州大学生体防御医学研究所トランスオミクス医学研究センター統合オミクス分野教授

J-GLOBAL ID: 201601019455499964
researchmap会員ID: 7000018740

外部リンク: http://www.bioreg.kyushu-u.ac.jp/labo/omics/

研究キーワード

研究分野

ライフサイエンス / システムゲノム科学 /

経歴

学歴

1998年4月 - 2001年3月

東京大学, 理学系研究科生物化学専攻博士課程
1996年4月 - 1998年3月

東京大学, 理学系研究科生物化学専攻修士課程
- 1996年3月

東京工業大学, 生命理工学部

論文

DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle

Hideki Maehara, Toshiya Kokaji, Atsushi Hatano, Yutaka Suzuki, Masaki Matsumoto, Keiichi I. Nakayama, Riku Egami, Takaho Tsuchiya, Haruka Ozaki, Keigo Morita …

Scientific Reports 13(1) 2023年11月5日
Comparison of hepatic responses to glucose perturbation between healthy and obese mice based on the edge type of network structures.

Yuki Ito, Shinsuke Uda, Toshiya Kokaji, Akiyoshi Hirayama, Tomoyoshi Soga, Yutaka Suzuki, Shinya Kuroda, Hiroyuki Kubota

Scientific reports 13(1) 4758-4758 2023年3月23日
In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Yuki Ito, Riku Egami …

2022年3月28日
Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism.

Saori Uematsu, Satoshi Ohno, Kaori Y Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-Ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto …

iScience 25(2) 103787-103787 2022年2月18日
Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans.

Suguru Fujita, Yasuaki Karasawa, Masashi Fujii, Ken-Ichi Hironaka, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Yohei Sumitomo, Akiyoshi Hirayama, Tomoyoshi Soga …

NPJ systems biology and applications 8(1) 6-6 2022年2月8日
An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver.

Fumiko Matsuzaki, Shinsuke Uda, Yukiyo Yamauchi, Masaki Matsumoto, Tomoyoshi Soga, Kazumitsu Maehara, Yasuyuki Ohkawa, Keiichi I Nakayama, Shinya Kuroda, Hiroyuki Kubota

Cell reports 36(8) 109569-109569 2021年8月24日
Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle

Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-ichi Hironaka, Saori Uematsu …

iScience 24(3) 102217-102217 2021年3月
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity.

Toshiya Kokaji, Atsushi Hatano, Yuki Ito, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Riku Egami …

Science signaling 13(660) 2020年12月1日
Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise.

Takumi Wada, Ken-Ichi Hironaka, Mitsutaka Wataya, Masashi Fujii, Miki Eto, Shinsuke Uda, Daisuke Hoshino, Katsuyuki Kunida, Haruki Inoue, Hiroyuki Kubota …

Cell reports 32(9) 108051-108051 2020年9月1日査読有り
Biophysics at Kyushu University.

Ryo Akiyama, Masahiko Annaka, Daisuke Kohda, Hiroyuki Kubota, Yusuke Maeda, Nobuaki Matsumori, Daisuke Mizuno, Norio Yoshida

Biophysical reviews 12(2) 245-247 2020年4月査読有り
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.

Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda …

Cell reports 29(9) 2901-2916 2019年11月26日査読有り
Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.

Masashi Fujii, Yohei Murakami, Yasuaki Karasawa, Yohei Sumitomo, Suguru Fujita, Masanori Koyama, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Katsumi Konishi …

NPJ systems biology and applications 5(1) 31-31 2019年9月2日査読有り
Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data.

Kentaro Kawata, Katsuyuki Yugi, Atsushi Hatano, Toshiya Kokaji, Yoko Tomizawa, Masashi Fujii, Shinsuke Uda, Hiroyuki Kubota, Masaki Matsumoto, Keiichi I Nakayama …

Genes to cells : devoted to molecular & cellular mechanisms 24(1) 82-93 2019年1月査読有り
Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.

Masashi Fujii, Yohei Murakami, Yasuaki Karasawa, Yohei Sumitomo, Suguru Fujita, Masanori Koyama, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Katsumi Konishi …

NPJ systems biology and applications 5 31-31 2019年査読有り
In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver.

Hiroyuki Kubota, Shinsuke Uda, Fumiko Matsuzaki, Yukiyo Yamauchi, Shinya Kuroda

Cell systems 7(5) 562-564 2018年11月28日査読有り
Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks.

Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y Tanaka, Shinsuke Uda …

iScience 7 212-229 2018年9月28日査読有り
In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver.

Kubota H, Uda S, Matsuzaki F, Yamauchi Y, Kuroda S

Cell systems 7(1) 118-128 2018年7月25日査読有り
Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects.

Kaoru Ohashi, Masashi Fujii, Shinsuke Uda, Hiroyuki Kubota, Hisako Komada, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

NPJ systems biology and applications 4 14-14 2018年査読有り
System identification of signaling dependent gene expression with different time-scale data.

Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda

PLoS computational biology 13(12) e1005913 2017年12月査読有り
System Identification Using Compressed Sensing Reveals Signaling-Decoding System by Gene Expression

Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda

2017年4月21日