論文

査読有り
2017年12月

Evolution of sequence-specific anti-silencing systems in Arabidopsis

NATURE COMMUNICATIONS
  • Aoi Hosaka
  • ,
  • Raku Saito
  • ,
  • Kazuya Takashima
  • ,
  • Taku Sasaki
  • ,
  • Yu Fu
  • ,
  • Akira Kawabe
  • ,
  • Tasuku Ito
  • ,
  • Atsushi Toyoda
  • ,
  • Asao Fujiyama
  • ,
  • Yoshiaki Tarutani
  • ,
  • Tetsuji Kakutani

8
1
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-017-02150-7
出版者・発行元
NATURE PUBLISHING GROUP

The arms race between parasitic sequences and their hosts is a major driving force for evolution of gene control systems. Since transposable elements (TEs) are potentially deleterious, eukaryotes silence them by epigenetic mechanisms such as DNA methylation. Little is known about how TEs counteract silencing to propagate during evolution. Here, we report behavior of sequence-specific anti-silencing proteins used by Arabidopsis TEs and evolution of those proteins and their target sequences. We show that VANC, a TE-encoded anti-silencing protein, induces extensive DNA methylation loss throughout TEs. Related VANC proteins have evolved to hypomethylate TEs of completely different spectra. Targets for VANC proteins often form tandem repeats, which vary considerably between related TEs. We propose that evolution of VANC proteins and their targets allow propagation of TEs while causing minimal host damage. Our findings provide insight into the evolutionary dynamics of these apparently "selfish" sequences. They also provide potential tools to edit epigenomes in a sequence-specific manner.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1038/s41467-017-02150-7
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418247100010&DestApp=WOS_CPL
URL
http://orcid.org/0000-0002-4412-6508
ID情報
  • DOI : 10.1038/s41467-017-02150-7
  • ISSN : 2041-1723
  • ORCIDのPut Code : 42185905
  • Web of Science ID : WOS:000418247100010

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