2010年5月
GERANYL DERIVATIVES OF ISOQUINOLINE ALKALOIDS SHOW INCREASED BIOLOGICAL ACTIVITIES
HETEROCYCLES
- 巻
- 81
- 号
- 5
- 開始ページ
- 1193
- 終了ページ
- 1229
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3987/COM-10-11912
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N- or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.
- リンク情報
- ID情報
-
- DOI : 10.3987/COM-10-11912
- ISSN : 0385-5414
- Web of Science ID : WOS:000278476600008