Papers

Jul, 1999

Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7-pentoxocanes and 1,2,4,5-tetroxanes

JOURNAL OF MEDICINAL CHEMISTRY
  • HS Kim
    • ,
  • Y Shibata
    • ,
  • Y Wataya
    • ,
  • K Tsuchiya
    • ,
  • A Masuyama
    • ,
  • M Nojima
Volume
42
Number
14
First page
2604
Last page
2609
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1021/jm990014j
Publisher
AMER CHEMICAL SOC
A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.
Link information
DOI
https://doi.org/10.1021/jm990014j
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000081532500011&DestApp=WOS_CPL
ID information
  • DOI : 10.1021/jm990014j
  • ISSN : 0022-2623
  • Web of Science ID : WOS:000081532500011
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