2001年6月
Synthesis and antimalarial activity of febrifugine derivatives
CHEMICAL & PHARMACEUTICAL BULLETIN
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 49
- 号
- 6
- 開始ページ
- 721
- 終了ページ
- 725
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/cpb.49.721
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
The regioisomers (2a,b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5 afforded a mixture of the trans and cis alcohols (6a,b) without diastereoselectivity: this result differentiated it from the reduction of 2-allyl-3-piperidone (14), The antimalarial activity of 2a,b and related compounds was tested.
- リンク情報
- ID情報
-
- DOI : 10.1248/cpb.49.721
- ISSN : 0009-2363
- Web of Science ID : WOS:000169024800013